6,6-bis[N-(1'S)-(1'-benzyl-2'-hydroxyethyl)carbamoyl]dibenzo[a,c]-1,3-cycloheptadiene

Base Information

• Chemical Name: 6,6-bis[N-(1'S)-(1'-benzyl-2'-hydroxyethyl)carbamoyl]dibenzo[a,c]-1,3-cycloheptadiene
• CAS No.: 545358-08-5
• Molecular Formula: C₃₅H₃₆N₂O₄
• Molecular Weight: 548.682
• Mol file: 545358-08-5.mol

Synonyms:6,6-bis[N-(1'S)-(1'-benzyl-2'-hydroxyethyl)carbamoyl]dibenzo[a,c]-1,3-cycloheptadiene

Chemical Property of 6,6-bis[N-(1'S)-(1'-benzyl-2'-hydroxyethyl)carbamoyl]dibenzo[a,c]-1,3-cycloheptadiene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,6-bis[N-(1'S)-(1'-benzyl-2'-hydroxyethyl)carbamoyl]dibenzo[a,c]-1,3-cycloheptadiene

There total 3 articles about 6,6-bis[N-(1'S)-(1'-benzyl-2'-hydroxyethyl)carbamoyl]dibenzo[a,c]-1,3-cycloheptadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-Phenylalaninol (3182-95-4) + 5,7-dihydro-dibenzo[a,c]cycloheptene-6,6-dicarbonyl dichloride → 6,6-bis[N-(1'S)-(1'-benzyl-2'-hydroxyethyl)carbamoyl]dibenzo[a,c]-1,3-cycloheptadiene (545358-08-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/S0040-4020(03)00144-3

Reference yield:

5,7-dihydro-dibenzo[a,c]cycloheptene-6,6-dicarboxylic acid diethyl ester (6672-66-8) → 6,6-bis[N-(1'S)-(1'-benzyl-2'-hydroxyethyl)carbamoyl]dibenzo[a,c]-1,3-cycloheptadiene (545358-08-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / methanol / 8 h / Heating

2: SOCl₂ / 2 h / Heating

3: 1.15 g / Et₃N / CH₂Cl₂ / 4 h / 20 °C

With sodium hydroxide; thionyl chloride; triethylamine; In methanol; dichloromethane;

DOI:10.1016/S0040-4020(03)00144-3

Reference yield:

dibenzo[a,c]-1,3-cycloheptadiene-6,6-dicarboxylic acid (109339-05-1) → 6,6-bis[N-(1'S)-(1'-benzyl-2'-hydroxyethyl)carbamoyl]dibenzo[a,c]-1,3-cycloheptadiene (545358-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 2 h / Heating

2: 1.15 g / Et₃N / CH₂Cl₂ / 4 h / 20 °C

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4020(03)00144-3

upstream raw materials:

L-Phenylalaninol

5,7-dihydro-dibenzo[a,c]cycloheptene-6,6-dicarboxylic acid diethyl ester

dibenzo[a,c]-1,3-cycloheptadiene-6,6-dicarboxylic acid