3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole

Base Information

• Chemical Name: 3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole
• CAS No.: 1585210-83-8
• Molecular Formula: C₂₈H₂₄N₄O₄
• Molecular Weight: 480.523
• Mol file: 1585210-83-8.mol

Synonyms:3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole

Chemical Property of 3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole

There total 12 articles about 3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole-3-carbaldehyde (1257393-90-0) + 4-methoxy-1,2-phenylenediamine (102-51-2) → 3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole (1585210-83-8)

Guidance literature:

With lanthanum(III) nitrate hexahydrate; In ethanol; for 0.5h; chemoselective reaction; Heating;

DOI:10.1039/c3ob42236d

Reference yield: 71.0%

1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole-3-carbaldehyde (1257393-90-0) + 4-methoxy-1,2-phenylenediamine (102-51-2) → 3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole (1585210-83-8) + C49H42N6O7

Guidance literature:

With sodium disulfite; In ethanol; water; at 70 ℃; for 8h; chemoselective reaction;

DOI:10.1039/c3ob42236d

Reference yield:

1-(3,4,5-trimethoxy-phenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester → 3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole (1585210-83-8)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfur / 5,5-dimethyl-1,3-cyclohexadiene / 12 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -5 - 20 °C

3: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

4: lanthanum(III) nitrate hexahydrate / ethanol / 0.5 h / Heating

With lithium aluminium tetrahydride; lanthanum(III) nitrate hexahydrate; Dess-Martin periodane; sulfur; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; dichloromethane;

DOI:10.1039/c3ob42236d

upstream raw materials:

L-Tryptophan

L-tryptophan methyl ester

1-(3,4,5-trimethoxyphenyl)-9H-pyrido[3,4-b]indole-3-carbaldehyde

4-methoxy-1,2-phenylenediamine