2'-O-methyl-5'-O-(monomethoxytrityl)-N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>guanosine 3'-<2-(4-nitrophenyl)ethyl diethylphosphoramidite>

Base Information

• Chemical Name: 2'-O-methyl-5'-O-(monomethoxytrityl)-N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>guanosine 3'-<2-(4-nitrophenyl)ethyl diethylphosphoramidite>
• CAS No.: 226882-13-9
• Molecular Formula: C₆₀H₆₂N₉O₁₅P
• Molecular Weight: 1180.18

Synonyms:2'-O-methyl-5'-O-(monomethoxytrityl)-N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>guanosine 3'-<2-(4-nitrophenyl)ethyl diethylphosphoramidite>

Chemical Property of 2'-O-methyl-5'-O-(monomethoxytrityl)-N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>guanosine 3'-<2-(4-nitrophenyl)ethyl diethylphosphoramidite>

Chemical Property:

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• Pictogram(s):  
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Technology Process of 2'-O-methyl-5'-O-(monomethoxytrityl)-N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>guanosine 3'-<2-(4-nitrophenyl)ethyl diethylphosphoramidite>

There total 3 articles about 2'-O-methyl-5'-O-(monomethoxytrityl)-N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>guanosine 3'-<2-(4-nitrophenyl)ethyl diethylphosphoramidite> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

chloro(diethylamino)<2-(4-nitrophenyl)ethoxy>phosphine (155865-87-5) + 2'-O-methyl-5'-O-(monomethoxytrityl)-N2-<2-(4-nitrophenyl)ethoxycarbonyl>-O6-<2-(4-nitrophenyl)ethyl>guanosine (185761-02-8) → 2'-O-methyl-5'-O-(monomethoxytrityl)-N2-<2-(4-nitrophenyl)ethoxycarbonyl>-O6-<2-(4-nitrophenyl)ethyl>guanosine 3'-<2-(4-nitrophenyl)ethyl diethylphosphoramidite> (226882-13-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; Ambient temperature;

DOI:10.1002/(SICI)1522-2675(19990407)82:4<614::AID-HLCA614>3.0.CO;2-Y

Reference yield:

2-(4-nitrophenyl)ethyl phosphorodichloridite (76101-32-1) → 2'-O-methyl-5'-O-(monomethoxytrityl)-N2-<2-(4-nitrophenyl)ethoxycarbonyl>-O6-<2-(4-nitrophenyl)ethyl>guanosine 3'-<2-(4-nitrophenyl)ethyl diethylphosphoramidite> (226882-13-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / diethyl ether / 1.) 0 deg C, 1 h; 2.) RT, 2 h

2: 83 percent / (iPr)2EtN / tetrahydrofuran / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether;

DOI:10.1002/(SICI)1522-2675(19990407)82:4<614::AID-HLCA614>3.0.CO;2-Y

Reference yield:

chloro(diethylamino)<2-(4-nitrophenyl)ethoxy>phosphine (155865-87-5) + 2'-O-methyl-5'-O-(monomethoxytrityl)-N2-<2-(4-nitrophenyl)ethoxycarbonyl>-O6-<2-(4-nitrophenyl)ethyl>guanosine (185761-02-8) → 2'-O-methyl-5'-O-(monomethoxytrityl)-N2-<2-(4-nitrophenyl)ethoxycarbonyl>-O6-<2-(4-nitrophenyl)ethyl>guanosine 3'-<2-(4-nitrophenyl)ethyl diethylphosphoramidite> (226882-13-9) + C72H79N11O18P2

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; Ambient temperature;

DOI:10.1002/(SICI)1522-2675(19990407)82:4<614::AID-HLCA614>3.0.CO;2-Y

upstream raw materials:

chloro(diethylamino)<2-(4-nitrophenyl)ethoxy>phosphine

2'-O-methyl-5'-O-(monomethoxytrityl)-N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>guanosine

2-(4-nitrophenyl)ethyl phosphorodichloridite

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