(+/-)-N'-(3,5-dichlorophenyl)-2-(4-fluoro-1-naphthalenyl)-2-(4-methyl-1-piperazinyl)ethanohydrazide

Base Information

• Chemical Name: (+/-)-N'-(3,5-dichlorophenyl)-2-(4-fluoro-1-naphthalenyl)-2-(4-methyl-1-piperazinyl)ethanohydrazide
• CAS No.: 1092476-38-4
• Molecular Formula: C₂₃H₂₃Cl₂FN₄O
• Molecular Weight: 461.366
• Mol file: 1092476-38-4.mol

Synonyms:(+/-)-N'-(3,5-dichlorophenyl)-2-(4-fluoro-1-naphthalenyl)-2-(4-methyl-1-piperazinyl)ethanohydrazide

Chemical Property of (+/-)-N'-(3,5-dichlorophenyl)-2-(4-fluoro-1-naphthalenyl)-2-(4-methyl-1-piperazinyl)ethanohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-N'-(3,5-dichlorophenyl)-2-(4-fluoro-1-naphthalenyl)-2-(4-methyl-1-piperazinyl)ethanohydrazide

There total 2 articles about (+/-)-N'-(3,5-dichlorophenyl)-2-(4-fluoro-1-naphthalenyl)-2-(4-methyl-1-piperazinyl)ethanohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.5%

(+/-)-(4-fluoro-1-naphthalenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride (1092477-63-8) + 3,5-dichlorophenylhydrazine (39943-56-1) → (+/-)-N'-(3,5-dichlorophenyl)-2-(4-fluoro-1-naphthalenyl)-2-(4-methyl-1-piperazinyl)ethanohydrazide (1092476-38-4)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

1-methyl-piperazine (109-01-3) + (4-fluoronaphthalen-1-yl)boronic acid (182344-25-8) → (+/-)-N'-(3,5-dichlorophenyl)-2-(4-fluoro-1-naphthalenyl)-2-(4-methyl-1-piperazinyl)ethanohydrazide (1092476-38-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 0.33 h / 20 - 120 °C / Microwave irradiation

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

(+/-)-(4-fluoro-1-naphthalenyl)(4-methyl-1-piperazinyl)acetic acid hydrochloride

3,5-dichlorophenylhydrazine

1-methyl-piperazine

(4-fluoronaphthalen-1-yl)boronic acid