methyl 4-((2-(1-(2-iodoethoxy)-3-phenylprop-2-yn-1-yl)phenyl)ethynyl)benzoate

Base Information

Chemical Name:methyl 4-((2-(1-(2-iodoethoxy)-3-phenylprop-2-yn-1-yl)phenyl)ethynyl)benzoate
CAS No.:1581741-24-3
Molecular Formula:C₂₇H₂₁IO₃
Molecular Weight:520.366
Hs Code.:

Synonyms:methyl 4-((2-(1-(2-iodoethoxy)-3-phenylprop-2-yn-1-yl)phenyl)ethynyl)benzoate

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Chemical Property of methyl 4-((2-(1-(2-iodoethoxy)-3-phenylprop-2-yn-1-yl)phenyl)ethynyl)benzoate

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Technology Process of methyl 4-((2-(1-(2-iodoethoxy)-3-phenylprop-2-yn-1-yl)phenyl)ethynyl)benzoate

There total 6 articles about methyl 4-((2-(1-(2-iodoethoxy)-3-phenylprop-2-yn-1-yl)phenyl)ethynyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1581741-12-9
C₂₇H₂₂O₄

: 1581741-24-3
methyl 4-((2-(1-(2-iodoethoxy)-3-phenylprop-2-yn-1-yl)phenyl)ethynyl)benzoate

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1002/chem.201304092

Reference yield:

: 1590395-92-8
methyl 4-((2-formylphenyl)ethynyl)benzoate

: 1581741-24-3
methyl 4-((2-(1-(2-iodoethoxy)-3-phenylprop-2-yn-1-yl)phenyl)ethynyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: tetrahydrofuran; hexane / 11 h / 20 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 3 h / -60 °C / Inert atmosphere

4.1: triphenylphosphine; iodine; 1H-imidazole / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; n-butyllithium; iodine; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/chem.201304092

Reference yield:

: 6630-33-7
ortho-bromobenzaldehyde

: 1581741-24-3
methyl 4-((2-(1-(2-iodoethoxy)-3-phenylprop-2-yn-1-yl)phenyl)ethynyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide; triethylamine / 0.25 h / 23 °C / Inert atmosphere

1.2: 0.25 h / Inert atmosphere

1.3: 12 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: tetrahydrofuran; hexane / 11 h / 20 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 3 h / -60 °C / Inert atmosphere

5.1: triphenylphosphine; iodine; 1H-imidazole / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; copper(l) iodide; n-butyllithium; iodine; diisobutylaluminium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; 1.1: |Sonogashira Cross-Coupling / 1.2: |Sonogashira Cross-Coupling / 1.3: |Sonogashira Cross-Coupling;
DOI:10.1002/chem.201304092