2-[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]propan-2-ol

Base Information

Chemical Name:2-[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]propan-2-ol
CAS No.:1042442-77-2
Molecular Formula:C₂₀H₁₈FN₅O
Molecular Weight:363.394
Hs Code.:

Synonyms:2-[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]propan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]propan-2-ol

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Technology Process of 2-[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]propan-2-ol

There total 1 articles about 2-[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1042442-76-1
2-[2-(4-fluorophenyl)-3-(2-methanesulfonylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]propan-2-ol

: 1042442-77-2
2-[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]propan-2-ol

Guidance literature:: With ammonia; In tetrahydrofuran; at 20 ℃; for 12h; under 2585.81 Torr;
DOI:10.1016/j.ejmech.2007.09.013

Reference yield: 11.0%

: 1042442-77-2
2-[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]propan-2-ol

: 143-33-9,25596-52-5
sodium cyanide

: 64-19-7,77671-22-8
acetic acid

: 1042442-80-7
C₂₀H₁₉FN₆

Guidance literature:: 2-[3-(2-aminopyrimidin-4-yl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-7-yl]propan-2-ol; sodium cyanide; acetic acid; With sulfuric acid; at 90 ℃; for 2h;

With sodium hydroxide; at 90 ℃; for 3h; Further stages.;
DOI:10.1016/j.ejmech.2007.09.013