(1S,2R,3R)-ethyl 2-chloro-3-isopropyl-1-(2-phenylethyl)-2-((R)-p-tolylsulfinyl)cyclopropanecarboxylate

Base Information

Chemical Name:(1S,2R,3R)-ethyl 2-chloro-3-isopropyl-1-(2-phenylethyl)-2-((R)-p-tolylsulfinyl)cyclopropanecarboxylate
CAS No.:1312031-68-7
Molecular Formula:C₂₄H₂₉ClO₃S
Molecular Weight:433.011
Hs Code.:

Synonyms:(1S,2R,3R)-ethyl 2-chloro-3-isopropyl-1-(2-phenylethyl)-2-((R)-p-tolylsulfinyl)cyclopropanecarboxylate

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Chemical Property of (1S,2R,3R)-ethyl 2-chloro-3-isopropyl-1-(2-phenylethyl)-2-((R)-p-tolylsulfinyl)cyclopropanecarboxylate

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Technology Process of (1S,2R,3R)-ethyl 2-chloro-3-isopropyl-1-(2-phenylethyl)-2-((R)-p-tolylsulfinyl)cyclopropanecarboxylate

There total 1 articles about (1S,2R,3R)-ethyl 2-chloro-3-isopropyl-1-(2-phenylethyl)-2-((R)-p-tolylsulfinyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 123849-08-1
(-)-(R)-dichloromethyl p-tolyl sulfoxide

: 1312031-62-1
(E)-4-methyl-2-(2-phenylethyl)pent-2-enoic acid ethyl ester

: 1312031-68-7
(1S,2R,3R)-ethyl 2-chloro-3-isopropyl-1-(2-phenylethyl)-2-((R)-p-tolylsulfinyl)cyclopropanecarboxylate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -85 - 20 ℃; optical yield given as %ee; Inert atmosphere;
DOI:10.1016/j.tet.2011.11.085

Reference yield: 99.0%

: 1312031-68-7
(1S,2R,3R)-ethyl 2-chloro-3-isopropyl-1-(2-phenylethyl)-2-((R)-p-tolylsulfinyl)cyclopropanecarboxylate

: [(1S,2R,3R)-2-chloro-3-isopropyl-1-(2-phenylethyl)-2-((R)-p-tolylsulfinyl)cyclopropyl]methanol

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 ℃;
DOI:10.1016/j.tetlet.2011.03.150

Reference yield:

: 1312031-68-7
(1S,2R,3R)-ethyl 2-chloro-3-isopropyl-1-(2-phenylethyl)-2-((R)-p-tolylsulfinyl)cyclopropanecarboxylate

: C₁₅H₂₀O

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 0 °C

2: isopropylmagnesium chloride / toluene / 0.5 h / 0 °C

With sodium tetrahydroborate; isopropylmagnesium chloride; In ethanol; toluene; 2: Doering-LaFlamme allene synthesis;
DOI:10.1016/j.tetlet.2011.03.150