3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol

Base Information

Chemical Name:3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol
CAS No.:1352306-64-9
Molecular Formula:C₃₀H₃₃NO₄
Molecular Weight:471.596
Hs Code.:

Synonyms:3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol

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Chemical Property of 3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol

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Technology Process of 3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol

There total 15 articles about 3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1352427-10-1
(3R)-3-methyl-1-((2S)-1-(4-(4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-3-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)propan-2-yl)pyrrolidine

: 1352306-64-9
3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol

Guidance literature:: (3R)-3-methyl-1-((2S)-1-(4-(4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-3-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)propan-2-yl)pyrrolidine; With water; acetic acid; at 90 ℃; for 0.25h;

With sodium hydrogencarbonate;

Reference yield:

: 2938-98-9,70423-38-0,101978-85-2,22644-28-6
(R)-2-methylbutane-1,4-diol

: 1352306-64-9
3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1.5 h / -20 - -15 °C

2: 24 h / 20 °C

3: caesium carbonate / copper(l) iodide / propyl cyanide / 125 °C / Inert atmosphere

4: water; acetic acid / 0.25 h / 90 °C

With water; caesium carbonate; acetic acid; triethylamine; copper(l) iodide; In propyl cyanide; dichloromethane;

Reference yield:

: (+)-(R)-2-methylbutane-1,4-diyl dimethanesulfonate

: 1352306-64-9
3-(3-hydroxyphenyl)-4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-2H-chromen-6-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 24 h / 20 °C

2: caesium carbonate / copper(l) iodide / propyl cyanide / 125 °C / Inert atmosphere

3: water; acetic acid / 0.25 h / 90 °C

With water; caesium carbonate; acetic acid; copper(l) iodide; In propyl cyanide;