2-(2,5-dimethylphenyl)-1-hydroxy-8-methoxy-4,8-diazaspiro[4.5]dec-1-en-3-one

Base Information

• Chemical Name: 2-(2,5-dimethylphenyl)-1-hydroxy-8-methoxy-4,8-diazaspiro[4.5]dec-1-en-3-one
• CAS No.: 1145784-37-7
• Molecular Formula: C₁₇H₂₂N₂O₃
• Molecular Weight: 302.373

Synonyms:2-(2,5-dimethylphenyl)-1-hydroxy-8-methoxy-4,8-diazaspiro[4.5]dec-1-en-3-one

Chemical Property of 2-(2,5-dimethylphenyl)-1-hydroxy-8-methoxy-4,8-diazaspiro[4.5]dec-1-en-3-one

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Technology Process of 2-(2,5-dimethylphenyl)-1-hydroxy-8-methoxy-4,8-diazaspiro[4.5]dec-1-en-3-one

There total 1 articles about 2-(2,5-dimethylphenyl)-1-hydroxy-8-methoxy-4,8-diazaspiro[4.5]dec-1-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

methyl 4-[[2-(2,5-dimethylphenyl)acetyl]amino]-1-methoxy-piperidine-4-carboxylate (1145784-79-7) → 2-(2,5-dimethylphenyl)-1-hydroxy-8-methoxy-4,8-diazaspiro[4.5]dec-1-en-3-one (1145784-37-7)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 18h;

Reference yield:

2-(2,5-dimethylphenyl)-1-hydroxy-8-methoxy-4,8-diazaspiro[4.5]dec-1-en-3-one (1145784-37-7) + ethyl chloromethyl ether (3188-13-4) → 3-(2,5-dimethyl-phenyl)-4-ethoxymethoxy-8-methoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one (1145783-33-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 20h;

Reference yield:

2-(2,5-dimethylphenyl)-1-hydroxy-8-methoxy-4,8-diazaspiro[4.5]dec-1-en-3-one (1145784-37-7) + methyl chloroformate (79-22-1) → carbonic acid 3-(2,5-dimethyl-phenyl)-8-methoxy-2-oxo-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester methyl ester (1145783-27-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In chlorobenzene; at 50 ℃; for 1h;

upstream raw materials:

methyl 4-[[2-(2,5-dimethylphenyl)acetyl]amino]-1-methoxy-piperidine-4-carboxylate

Downstream raw materials:

3-(2,5-dimethyl-phenyl)-4-ethoxymethoxy-8-methoxy-1,8-diaza-spiro[4.5]dec-3-en-2-one

carbonic acid 3-(2,5-dimethyl-phenyl)-8-methoxy-2-oxo-1,8-diaza-spiro[4.5]dec-3-en-4-yl ester methyl ester

3-chloro-3-(2,5-dimethylphenyl)-8-methoxy-1,8-diazaspiro[4.5]decane-2,4-dione

3-(2,5-dimethylphenyl)-3-fluoro-8-methoxy-1,8-diazaspiro[4.5]decane-2,4-dione

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