Technology Process of 1-Cyclohexene-1-carboxylicacid,4-hydroxy-3-oxo-,(S)-(9CI)
There total 10 articles about 1-Cyclohexene-1-carboxylicacid,4-hydroxy-3-oxo-,(S)-(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: p-TSA / toluene / 22 h / Heating
2: 82 percent / NaH, Bu4NI / CH2Cl2 / 70 h
3: 59 percent / MeONa / 1 h / Ambient temperature
4: pyridine / CH2Cl2 / 1 h / Ambient temperature
5: DBU / CHCl3 / 3 h / Heating
6: H2 / 5percent Pd/C / CH2Cl2 / 48 h
7: 43 percent / aq. K2CO3 / methanol / 24 h / Ambient temperature
8: 20 percent / aq. HNO3 / 1.) r.t., 30 min. 2.) 0 deg C, 60 h
9: 25 °C / dehydroquinase from Escherichia coli
With
pyridine; hydrogen; nitric acid; sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium on activated charcoal;
In
methanol; dichloromethane; chloroform; toluene;
DOI:10.1039/p19960002371
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 59 percent / MeONa / 1 h / Ambient temperature
2: pyridine / CH2Cl2 / 1 h / Ambient temperature
3: DBU / CHCl3 / 3 h / Heating
4: H2 / 5percent Pd/C / CH2Cl2 / 48 h
5: 43 percent / aq. K2CO3 / methanol / 24 h / Ambient temperature
6: 20 percent / aq. HNO3 / 1.) r.t., 30 min. 2.) 0 deg C, 60 h
7: 25 °C / dehydroquinase from Escherichia coli
With
pyridine; hydrogen; nitric acid; sodium methylate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
palladium on activated charcoal;
In
methanol; dichloromethane; chloroform;
DOI:10.1039/p19960002371
