4-(1-(5-(3-hydroxy-2-oxopyridin-1(2H)-yl)pentyl)-1H-1,2,3-triazol-4-yl)-2-(trifluoromethyl)benzonitrile

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Chemical Name:4-(1-(5-(3-hydroxy-2-oxopyridin-1(2H)-yl)pentyl)-1H-1,2,3-triazol-4-yl)-2-(trifluoromethyl)benzonitrile
CAS No.:1416915-67-7
Molecular Formula:C₂₀H₁₈F₃N₅O₂
Molecular Weight:417.39
Hs Code.:

Synonyms:4-(1-(5-(3-hydroxy-2-oxopyridin-1(2H)-yl)pentyl)-1H-1,2,3-triazol-4-yl)-2-(trifluoromethyl)benzonitrile

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Chemical Property of 4-(1-(5-(3-hydroxy-2-oxopyridin-1(2H)-yl)pentyl)-1H-1,2,3-triazol-4-yl)-2-(trifluoromethyl)benzonitrile

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Technology Process of 4-(1-(5-(3-hydroxy-2-oxopyridin-1(2H)-yl)pentyl)-1H-1,2,3-triazol-4-yl)-2-(trifluoromethyl)benzonitrile

There total 7 articles about 4-(1-(5-(3-hydroxy-2-oxopyridin-1(2H)-yl)pentyl)-1H-1,2,3-triazol-4-yl)-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1510708-63-0
4-(1-(5-(3-methoxy-2-oxopyridin-1(2H)-yl)pentyl)-1H-1,2,3-triazol-4-yl)-2-(trifluoromethyl)benzonitrile

: 1416915-67-7
4-(1-(5-(3-hydroxy-2-oxopyridin-1(2H)-yl)pentyl)-1H-1,2,3-triazol-4-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: 4-(1-(5-(3-methoxy-2-oxopyridin-1(2H)-yl)pentyl)-1H-1,2,3-triazol-4-yl)-2-(trifluoromethyl)benzonitrile; With boron tribromide; In dichloromethane; at -30 - 20 ℃; for 48h; Inert atmosphere;

With methanol; In dichloromethane; at -30 ℃; Inert atmosphere;
DOI:10.1021/jm401225q

Reference yield:

: 1510708-92-5
2-(trifluoromethyl)-4-((trimethylsilyl)ethynyl)benzonitrile

: 1416915-67-7
4-(1-(5-(3-hydroxy-2-oxopyridin-1(2H)-yl)pentyl)-1H-1,2,3-triazol-4-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

2.1: copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 48 h / -30 - 20 °C / Inert atmosphere

3.2: -30 °C / Inert atmosphere

With copper(l) iodide; tetrabutyl ammonium fluoride; boron tribromide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; 2.1: |Huisgen Cycloaddition;
DOI:10.1021/jm401225q

Reference yield:

: 1-azido-5-methanesulfonylpentane

: 1416915-67-7
4-(1-(5-(3-hydroxy-2-oxopyridin-1(2H)-yl)pentyl)-1H-1,2,3-triazol-4-yl)-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; methanol / 48 h / 80 °C

2.1: copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

3.1: boron tribromide / dichloromethane / 48 h / -30 - 20 °C / Inert atmosphere

3.2: -30 °C / Inert atmosphere

With copper(l) iodide; boron tribromide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; 2.1: |Huisgen Cycloaddition;
DOI:10.1021/jm401225q