6'-(2-Methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)spiro[cyclopentane-1,3'-indolin]-2'-one

Base Information

Chemical Name:6'-(2-Methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)spiro[cyclopentane-1,3'-indolin]-2'-one
CAS No.:1190861-12-1
Molecular Formula:C₂₂H₂₁N₃O₂
Molecular Weight:359.428
Hs Code.:

Synonyms:6'-(2-Methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)spiro[cyclopentane-1,3'-indolin]-2'-one

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Chemical Property of 6'-(2-Methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)spiro[cyclopentane-1,3'-indolin]-2'-one

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Technology Process of 6'-(2-Methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)spiro[cyclopentane-1,3'-indolin]-2'-one

There total 3 articles about 6'-(2-Methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)spiro[cyclopentane-1,3'-indolin]-2'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1190966-15-4
(E)-N'-hydroxy-4-methyl-3-(2'-oxospiro[cyclopentane-1,3'-indoline]-6'-yl)benzimidamide

: 108-24-7
acetic anhydride

: 1190861-12-1
6'-(2-Methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)spiro[cyclopentane-1,3'-indolin]-2'-one

Guidance literature:: at 130 ℃; for 1h;

Reference yield:

: 1345842-18-3
C₈H₉IN₂O

: 1190861-12-1
6'-(2-Methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)spiro[cyclopentane-1,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 2 steps

1: 130 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 100 - 110 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.09.006

Reference yield:

: 42872-79-7
3-iodo-4-methylbenzonitrile

: 1190861-12-1
6'-(2-Methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)spiro[cyclopentane-1,3'-indolin]-2'-one

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 65 °C

2: 130 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 100 - 110 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; hydroxylamine hydrochloride; sodium acetate; caesium carbonate; In 1,4-dioxane; ethanol; water; 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2011.09.006