1-Naphthalenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

Base Information

Chemical Name:1-Naphthalenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester
CAS No.:189340-53-2
Molecular Formula:C₂₈H₃₃NO₆S
Molecular Weight:511.639
Hs Code.:

Synonyms:1-Naphthalenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

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Chemical Property of 1-Naphthalenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

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Technology Process of 1-Naphthalenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

There total 5 articles about 1-Naphthalenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85-46-1
1-Naphthalenesulfonyl chloride

: 161975-39-9
tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate

: 189340-49-6
1-naphthalenesulfonic acid 3-hydroxy-5-methylphenyl ester

: 189340-53-2
1-Naphthalenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

Guidance literature:: 1-Naphthalenesulfonyl chloride; 1-naphthalenesulfonic acid 3-hydroxy-5-methylphenyl ester; With sodium hydride; In N,N-dimethyl-formamide;

tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate; In N,N-dimethyl-formamide; at 50 ℃; for 3h;
DOI:10.1016/S0960-894X(99)00617-4

Reference yield:

: 498-94-2
isonipecotic acid

: 189340-53-2
1-Naphthalenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / NaHCO₃ / dioxane; H₂O / 24 h

2.1: 84 percent / BH₃*THF / 0 - 25 °C

3.1: 93 percent / Et₃N / CH₂Cl₂

4.1: NaH / dimethylformamide

4.2: dimethylformamide / 3 h / 50 °C

With borane-THF; sodium hydride; sodium hydrogencarbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Acylation / 2.1: Reduction / 3.1: Mesylation / 4.1: Metallation / 4.2: Substitution;
DOI:10.1016/S0960-894X(99)00617-4

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 189340-53-2
1-Naphthalenesulfonic acid 3-[[N-(tert-butoxycarbonyl)piperidin-4-yl]methoxy]-5-methylphenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / NaHCO₃ / dioxane; H₂O / 24 h

2.1: 84 percent / BH₃*THF / 0 - 25 °C

3.1: 93 percent / Et₃N / CH₂Cl₂

4.1: NaH / dimethylformamide

4.2: dimethylformamide / 3 h / 50 °C

With borane-THF; sodium hydride; sodium hydrogencarbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Acylation / 2.1: Reduction / 3.1: Mesylation / 4.1: Metallation / 4.2: Substitution;
DOI:10.1016/S0960-894X(99)00617-4