(1R,2R)-1-amino-6-nitroindan-2-ol (S)-(+)-mandelic acid salt

Base Information

• Chemical Name: (1R,2R)-1-amino-6-nitroindan-2-ol (S)-(+)-mandelic acid salt
• CAS No.: 505083-09-0
• Molecular Formula: C₈H₈O₃*C₉H₁₀N₂O₃
• Molecular Weight: 346.34
• Mol file: 505083-09-0.mol

Synonyms:(1R,2R)-1-amino-6-nitroindan-2-ol (S)-(+)-mandelic acid salt

Chemical Property of (1R,2R)-1-amino-6-nitroindan-2-ol (S)-(+)-mandelic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-1-amino-6-nitroindan-2-ol (S)-(+)-mandelic acid salt

There total 1 articles about (1R,2R)-1-amino-6-nitroindan-2-ol (S)-(+)-mandelic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

(S)-Mandelic acid (17199-29-0) + 1,2-epoxy-6-nitroindane (124369-38-6) → (1R,2R)-1-amino-6-nitroindan-2-ol (S)-(+)-mandelic acid salt (505083-09-0)

Guidance literature:

1,2-epoxy-6-nitroindane; With ammonium hydroxide; In water; at 36 ℃; for 21h; Large scale reaction;

(S)-Mandelic acid; at 55 ℃; for 2h; optical yield given as %ee; Large scale reaction;

DOI:10.1021/op800243q

Reference yield:

4-biphenyl-carboxylic acid chloride (14002-51-8) + (1R,2R)-1-amino-6-nitroindan-2-ol (S)-(+)-mandelic acid salt (505083-09-0) → N-((1R,2R)-2-hydroxy-6-nitro-indan-1-yl)-biphenyl-4-carboxamide (505083-10-3) + C35H26N2O5 (1108748-13-5) + biphenyl-4-carboxylic acid (92-92-2)

Guidance literature:

(1R,2R)-1-amino-6-nitroindan-2-ol (S)-(+)-mandelic acid salt; With sodium hydroxide; In water; toluene; for 1h; Large scale reaction;

4-biphenyl-carboxylic acid chloride; In water; toluene; for 22h; Large scale reaction;

DOI:10.1021/op800243q

upstream raw materials:

(S)-Mandelic acid

1,2-epoxy-6-nitroindane

Downstream raw materials:

N-((1R,2R)-2-hydroxy-6-nitro-indan-1-yl)-biphenyl-4-carboxamide

C₃₅H₂₆N₂O₅

biphenyl-4-carboxylic acid