rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-(1-hydroxyethyl)-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)ethyl>-4-oxo-2-azetidinyl>acetyl>me.

Base Information

Chemical Name:rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-(1-hydroxyethyl)-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)ethyl>-4-oxo-2-azetidinyl>acetyl>me.
CAS No.:138444-28-7
Molecular Formula:C₅₁H₅₄F₃N₄O₁₀P
Molecular Weight:970.98
Hs Code.:

rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-(1-hydroxyethyl)-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)ethyl>-4-oxo-2-azetidinyl>acetyl>me.

Synonyms:rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-(1-hydroxyethyl)-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)ethyl>-4-oxo-2-azetidinyl>acetyl>me.

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Chemical Property of rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-(1-hydroxyethyl)-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)ethyl>-4-oxo-2-azetidinyl>acetyl>me.

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Technology Process of rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-(1-hydroxyethyl)-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)ethyl>-4-oxo-2-azetidinyl>acetyl>me.

There total 2 articles about rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-(1-hydroxyethyl)-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)ethyl>-4-oxo-2-azetidinyl>acetyl>me. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 115699-47-3
6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid potassium salt

: 138423-45-7
rac-<2R,3S(R)>-2-(3-bromo-2-oxopropyl)-3-(1-hydroxyethyl)-4-oxo-α-(triphenylphosphoranylidene)azetidine-1-acetic acid (2,2-dimethyl-1-oxopropoxy)methyl ester

: 138444-28-7
rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-(1-hydroxyethyl)-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)ethyl>-4-oxo-2-azetidinyl>acetyl>me.

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 17h; Ambient temperature;
DOI:10.1021/jm00088a019

Reference yield:

: 138423-44-6
rac-<2R,3S(R)>-2-(3-bromo-2,2-dimethoxypropyl)-3-(1-hydroxyethyl)-4-oxo-α-(triphenylphosphoranylidene)-1-azetidineacetic acid (2,2-dimethyl-1-oxopropyl)methyl ester

: 138444-28-7
rac-<2R,3S(R)>-6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid <<3-(1-hydroxyethyl)-1-<2-<(2,2-dimethyl-1-oxopropoxy)methoxy>-2-oxo-1-(triphenylphosphoranylidene)ethyl>-4-oxo-2-azetidinyl>acetyl>me.

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / 48percent aq. HBr / acetone / 0.33 h / 0 °C

2: 63 percent / Et₃N / dimethylformamide / 17 h / Ambient temperature

With hydrogen bromide; triethylamine; In N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00088a019