trans-8-chloro-1-[4-(pyridin-2-yloxy)-cyclohexyl]-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

Base Information

Chemical Name:trans-8-chloro-1-[4-(pyridin-2-yloxy)-cyclohexyl]-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester
CAS No.:1228088-28-5
Molecular Formula:C₂₆H₃₀ClN₅O₃
Molecular Weight:496.009
Hs Code.:

Synonyms:trans-8-chloro-1-[4-(pyridin-2-yloxy)-cyclohexyl]-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

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Chemical Property of trans-8-chloro-1-[4-(pyridin-2-yloxy)-cyclohexyl]-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

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Technology Process of trans-8-chloro-1-[4-(pyridin-2-yloxy)-cyclohexyl]-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

There total 10 articles about trans-8-chloro-1-[4-(pyridin-2-yloxy)-cyclohexyl]-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1226808-00-9
7-chloro-2-oxo-1,2,3,5-tetrahydrobenzo[1,4]diazepine-4-carboxylic acid tert-butyl ester

: 1228088-28-5
trans-8-chloro-1-[4-(pyridin-2-yloxy)-cyclohexyl]-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Lawessons reagent / tetrahydrofuran / 3 h / Reflux

2: butan-1-ol / Reflux

With Lawessons reagent; In tetrahydrofuran; butan-1-ol;
DOI:10.1021/acs.jmedchem.9b01478

Reference yield:

: 57750-81-9
4-chloro-2-(chloromethyl)-1-nitrobenzene

: 1228088-28-5
trans-8-chloro-1-[4-(pyridin-2-yloxy)-cyclohexyl]-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / ethanol / 8 h / Reflux

2.1: dmap / dichloromethane / 18 h / 0 - 20 °C

3.1: zinc dibromide / ethyl acetate / 0.25 h / Inert atmosphere

3.2: 48 h / 20 °C / 750.08 Torr

4.1: potassium tert-butylate / tetrahydrofuran / 3 h / 5 - 20 °C

5.1: Lawessons reagent / tetrahydrofuran / 3 h / Reflux

6.1: butan-1-ol / Reflux

With Lawessons reagent; dmap; potassium tert-butylate; triethylamine; zinc dibromide; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; butan-1-ol;
DOI:10.1021/acs.jmedchem.9b01478

Reference yield:

: 1226807-99-3
[(2-amino-5-chlorobenzyl)-tert-butoxycarbonylamino]acetic acid ethyl ester

: 1228088-28-5
trans-8-chloro-1-[4-(pyridin-2-yloxy)-cyclohexyl]-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 3 h / 5 - 20 °C

2: Lawessons reagent / tetrahydrofuran / 3 h / Reflux

3: butan-1-ol / Reflux

With Lawessons reagent; potassium tert-butylate; In tetrahydrofuran; butan-1-ol;
DOI:10.1021/acs.jmedchem.9b01478