(2R,4aR,5S,7aS)-hexahydro-4a-methyl-2-phenylcyclopenta[d][1,3]-dioxin-5-ol

Base Information

Chemical Name:(2R,4aR,5S,7aS)-hexahydro-4a-methyl-2-phenylcyclopenta[d][1,3]-dioxin-5-ol
CAS No.:856178-06-8
Molecular Formula:C₁₄H₁₈O₃
Molecular Weight:234.295
Hs Code.:

Synonyms:(2R,4aR,5S,7aS)-hexahydro-4a-methyl-2-phenylcyclopenta[d][1,3]-dioxin-5-ol

Suppliers and Price of (2R,4aR,5S,7aS)-hexahydro-4a-methyl-2-phenylcyclopenta[d][1,3]-dioxin-5-ol

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Chemical Property of (2R,4aR,5S,7aS)-hexahydro-4a-methyl-2-phenylcyclopenta[d][1,3]-dioxin-5-ol

Chemical Property:

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Technology Process of (2R,4aR,5S,7aS)-hexahydro-4a-methyl-2-phenylcyclopenta[d][1,3]-dioxin-5-ol

There total 10 articles about (2R,4aR,5S,7aS)-hexahydro-4a-methyl-2-phenylcyclopenta[d][1,3]-dioxin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 856177-89-4
2-((benzyloxy)methyl)-2-methylcyclopentane-1,3-dione

: 856178-06-8
(2R,4aR,5S,7aS)-hexahydro-4a-methyl-2-phenylcyclopenta[d][1,3]-dioxin-5-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / baker's yeast; sucrose; yeast extract / triton X-100 / H₂O; ethanol / 48 h / 30 °C

2: 100 percent / Me₄NBH(OAc)3; acetic acid / dimethylformamide / 48 h / 20 °C

3: H₂; Raney Ni / methanol; H₂O / 24 h / 20 °C / 760 Torr

4: 658 mg / (-)-CSA / CH₂Cl₂ / 6 h / Heating

With baker's yeast; (-)-camphor-10-sulfonic acid; hydrogen; nickel; acetic acid; tetramethylammonium triacetoxyborohydride; yeast extract; Sucrose; Triton X-100; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo050349a

Reference yield:

: 856177-83-8
(6-methyl-1,4,8,11-tetraoxadispiro[4.1.4.2]tridec-6-yl)methanol

: 856178-06-8
(2R,4aR,5S,7aS)-hexahydro-4a-methyl-2-phenylcyclopenta[d][1,3]-dioxin-5-ol

Guidance literature:: Multi-step reaction with 6 steps

1: NaH; TBAI / tetrahydrofuran; dimethylformamide / 12 h / 0 - 20 °C

2: 7.93 g / HCl / tetrahydrofuran / 3 h / Heating

3: 73 percent / baker's yeast; sucrose; yeast extract / triton X-100 / H₂O; ethanol / 48 h / 30 °C

4: 100 percent / Me₄NBH(OAc)3; acetic acid / dimethylformamide / 48 h / 20 °C

5: H₂; Raney Ni / methanol; H₂O / 24 h / 20 °C / 760 Torr

6: 658 mg / (-)-CSA / CH₂Cl₂ / 6 h / Heating

With hydrogenchloride; baker's yeast; (-)-camphor-10-sulfonic acid; hydrogen; tetra-(n-butyl)ammonium iodide; nickel; sodium hydride; acetic acid; tetramethylammonium triacetoxyborohydride; yeast extract; Sucrose; Triton X-100; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo050349a

Reference yield:

: 856177-80-5
(E)-6-methyl-6-(1-propen-1-yl)-1,4,8,11-tetraoxadispiro[4.1.4.2]tridecane

: 856178-06-8
(2R,4aR,5S,7aS)-hexahydro-4a-methyl-2-phenylcyclopenta[d][1,3]-dioxin-5-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: ozone / methanol / 4 h / -78 °C

1.2: NaBH₄ / methanol / -78 - 20 °C

2.1: NaH; TBAI / tetrahydrofuran; dimethylformamide / 12 h / 0 - 20 °C

3.1: 7.93 g / HCl / tetrahydrofuran / 3 h / Heating

4.1: 73 percent / baker's yeast; sucrose; yeast extract / triton X-100 / H₂O; ethanol / 48 h / 30 °C

5.1: 100 percent / Me₄NBH(OAc)3; acetic acid / dimethylformamide / 48 h / 20 °C

6.1: H₂; Raney Ni / methanol; H₂O / 24 h / 20 °C / 760 Torr

7.1: 658 mg / (-)-CSA / CH₂Cl₂ / 6 h / Heating

With hydrogenchloride; baker's yeast; (-)-camphor-10-sulfonic acid; hydrogen; tetra-(n-butyl)ammonium iodide; nickel; sodium hydride; ozone; acetic acid; tetramethylammonium triacetoxyborohydride; yeast extract; Sucrose; Triton X-100; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo050349a