ethyl {5-[3-chloro-5-(5-pyrimidinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

Base Information

Chemical Name:ethyl {5-[3-chloro-5-(5-pyrimidinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate
CAS No.:1095274-53-5
Molecular Formula:C₁₆H₁₃ClN₄O₃
Molecular Weight:344.757
Hs Code.:

Synonyms:ethyl {5-[3-chloro-5-(5-pyrimidinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

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Chemical Property of ethyl {5-[3-chloro-5-(5-pyrimidinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

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Technology Process of ethyl {5-[3-chloro-5-(5-pyrimidinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

There total 7 articles about ethyl {5-[3-chloro-5-(5-pyrimidinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095274-52-4
ethyl [5-(3-bromo-5-chlorophenyl)-1,3,4-oxadiazol-2-yl]acetate

: 109299-78-7
pyrimidine 5-boronic acid

: 1095274-53-5
ethyl {5-[3-chloro-5-(5-pyrimidinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; at 100 ℃; for 0.666667h; Microwave irradion;

Reference yield:

: 42860-02-6
3‐bromo‐5‐chlorobenzoic acid

: 1095274-53-5
ethyl {5-[3-chloro-5-(5-pyrimidinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h / 20 °C

2: Burgess Reagent / dichloromethane / 0.33 h / 100 °C / Microwave irradition

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.67 h / 100 °C / Microwave irradion

With 4-methyl-morpholine; Burgess Reagent; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1095274-55-7
3-bromo-5-chlorobenzoic acid ethyl ester

: 1095274-53-5
ethyl {5-[3-chloro-5-(5-pyrimidinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine / ethanol / 80 °C

2: tetrahydrofuran / 0.33 h / 20 °C

3: Burgess Reagent / dichloromethane / 0.33 h / 100 °C / Microwave irradition

4: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.67 h / 100 °C / Microwave irradion

With Burgess Reagent; sodium carbonate; hydrazine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water;