[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-(tetrahydro-pyran-2-yloxycarbonylmethoxy)-propyl ester

Base Information

Chemical Name:[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-(tetrahydro-pyran-2-yloxycarbonylmethoxy)-propyl ester
CAS No.:165063-91-2
Molecular Formula:C₂₈H₂₈Cl₂F₃N₃O₁₀
Molecular Weight:694.446
Hs Code.:

[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-(tetrahydro-pyran-2-yloxycarbonylmethoxy)-propyl ester

Synonyms:[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-(tetrahydro-pyran-2-yloxycarbonylmethoxy)-propyl ester

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Chemical Property of [4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-(tetrahydro-pyran-2-yloxycarbonylmethoxy)-propyl ester

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Technology Process of [4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-(tetrahydro-pyran-2-yloxycarbonylmethoxy)-propyl ester

There total 3 articles about [4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-(tetrahydro-pyran-2-yloxycarbonylmethoxy)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 105113-62-0
4-<(trifluoroacetyl)amino>benzeneacetic acid

: 165063-85-4
[(2R,3R)-2-(2,2-Dichloro-acetylamino)-3-hydroxy-3-(4-nitro-phenyl)-propoxy]-acetic acid tetrahydro-pyran-2-yl ester

: 165063-91-2
[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-(tetrahydro-pyran-2-yloxycarbonylmethoxy)-propyl ester

Guidance literature:: With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; for 18h; Ambient temperature;
DOI:10.1021/ja00128a006

Reference yield:

: 56-75-7,85666-84-8
chloramphenicol

: 165063-91-2
[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-(tetrahydro-pyran-2-yloxycarbonylmethoxy)-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 80 min

2: 44 percent / 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, pyridine / 18 h / Ambient temperature

With pyridine; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
DOI:10.1021/ja00128a006

Reference yield:

: (tetrahydropyranyl)-iodoacetic acid

: 165063-91-2
[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (1R,2R)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-(tetrahydro-pyran-2-yloxycarbonylmethoxy)-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, 0 deg C, 10 min, 2.) THF, 0 deg C, 80 min

2: 44 percent / 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, pyridine / 18 h / Ambient temperature

With pyridine; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
DOI:10.1021/ja00128a006