5-({[(3-hydroxypropyl)amino]carbonyl}amino)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-4-carboxamide

Base Information

Chemical Name:5-({[(3-hydroxypropyl)amino]carbonyl}amino)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-4-carboxamide
CAS No.:1446246-95-2
Molecular Formula:C₂₂H₂₄N₆O₄S
Molecular Weight:468.536
Hs Code.:

Synonyms:5-({[(3-hydroxypropyl)amino]carbonyl}amino)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-4-carboxamide

Suppliers and Price of 5-({[(3-hydroxypropyl)amino]carbonyl}amino)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-4-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-({[(3-hydroxypropyl)amino]carbonyl}amino)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-4-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-({[(3-hydroxypropyl)amino]carbonyl}amino)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-4-carboxamide

There total 12 articles about 5-({[(3-hydroxypropyl)amino]carbonyl}amino)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1446247-91-1
C₂₄H₂₆N₆O₅S

: 1446246-95-2
5-({[(3-hydroxypropyl)amino]carbonyl}amino)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-4-carboxamide

Guidance literature:: With methanol; sodium methylate; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 2h;

Reference yield:

: 909028-96-2
3-amino-3-(4-nitrophenyl)-2-thioformamidoacrylonitrile

: 1446246-95-2
5-({[(3-hydroxypropyl)amino]carbonyl}amino)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: dihydrogen peroxide / ethanol / 22 h / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

2.2: 20 °C

3.1: sulfuric acid / 1.83 h / 45 °C

3.2: Cooling with ice

4.1: sodium tetrahydroborate / tetrahydrofuran / Reflux

4.2: 2 h / Reflux

5.1: pyridine / 2.16 h / 20 °C

6.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 4137.29 Torr / Autoclave

7.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; dimethyl sulfoxide / 2 h / 20 °C

8.1: sodium methylate; methanol / tetrahydrofuran; dimethyl sulfoxide / 2 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; sulfuric acid; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 605661-26-5
2-[amino(4-nitrophenyl)methylene]malononitrile

: 1446246-95-2
5-({[(3-hydroxypropyl)amino]carbonyl}amino)-3-[4-({[(4-methylphenyl)amino]carbonyl}amino)phenyl]isothiazol-4-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: O,O-Diethyl hydrogen phosphorodithioate / ethanol; water / 100 °C / Inert atmosphere

2.1: dihydrogen peroxide / ethanol / 22 h / Inert atmosphere

3.1: potassium carbonate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

3.2: 20 °C

4.1: sulfuric acid / 1.83 h / 45 °C

4.2: Cooling with ice

5.1: sodium tetrahydroborate / tetrahydrofuran / Reflux

5.2: 2 h / Reflux

6.1: pyridine / 2.16 h / 20 °C

7.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 4137.29 Torr / Autoclave

8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; dimethyl sulfoxide / 2 h / 20 °C

9.1: sodium methylate; methanol / tetrahydrofuran; dimethyl sulfoxide / 2 h / 20 °C

With pyridine; methanol; sodium tetrahydroborate; sulfuric acid; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; sodium methylate; potassium carbonate; O,O-Diethyl hydrogen phosphorodithioate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;