diethyl 2-[4-({(3S,5S,6R)-2-oxo-5,6-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]-2-hydroxypropane-1,3-dioate

Base Information

Chemical Name:diethyl 2-[4-({(3S,5S,6R)-2-oxo-5,6-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]-2-hydroxypropane-1,3-dioate
CAS No.:863719-48-6
Molecular Formula:C₃₈H₃₇NO₉
Molecular Weight:651.713
Hs Code.:

Synonyms:diethyl 2-[4-({(3S,5S,6R)-2-oxo-5,6-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]-2-hydroxypropane-1,3-dioate

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Chemical Property of diethyl 2-[4-({(3S,5S,6R)-2-oxo-5,6-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]-2-hydroxypropane-1,3-dioate

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Technology Process of diethyl 2-[4-({(3S,5S,6R)-2-oxo-5,6-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]-2-hydroxypropane-1,3-dioate

There total 3 articles about diethyl 2-[4-({(3S,5S,6R)-2-oxo-5,6-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]-2-hydroxypropane-1,3-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: Williams lactone lithium enolate

: 412014-15-4
diethyl 2-hydroxy-2-(4-methylphenyl)propane-1,3-dioate

: 863719-48-6
diethyl 2-[4-({(3S,5S,6R)-2-oxo-5,6-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]-2-hydroxypropane-1,3-dioate

Guidance literature:: diethyl 2-hydroxy-2-(4-methylphenyl)propane-1,3-dioate; With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 1h; Heating;

Williams lactone lithium enolate; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 - 20 ℃; for 16h;
DOI:10.1021/jm050154v

Reference yield:

: 108-88-3,15644-74-3,16713-13-6
toluene

: 863719-48-6
diethyl 2-[4-({(3S,5S,6R)-2-oxo-5,6-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]-2-hydroxypropane-1,3-dioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / SnCl₄ / 2 h / 20 °C

2.1: N-bromosuccinimide; AIBN / CCl₄ / 1 h / Heating

2.2: 30 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 16 h / -78 - 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tin(IV) chloride; In tetrachloromethane;
DOI:10.1021/jm050154v

Reference yield:

: 609-09-6
Diethyl ketomalonate

: 863719-48-6
diethyl 2-[4-({(3S,5S,6R)-2-oxo-5,6-diphenyl-4-[benzyloxycarbonyl]morpholin-3-yl}methyl)phenyl]-2-hydroxypropane-1,3-dioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / SnCl₄ / 2 h / 20 °C

2.1: N-bromosuccinimide; AIBN / CCl₄ / 1 h / Heating

2.2: 30 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 16 h / -78 - 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tin(IV) chloride; In tetrachloromethane;
DOI:10.1021/jm050154v