Benzyl-[1-((4S,5S)-5-methoxymethoxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-amine

Base Information

Chemical Name:Benzyl-[1-((4S,5S)-5-methoxymethoxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-amine
CAS No.:130675-65-9
Molecular Formula:C₁₆H₂₃NO₄
Molecular Weight:293.363
Hs Code.:

Synonyms:Benzyl-[1-((4S,5S)-5-methoxymethoxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-amine

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Chemical Property of Benzyl-[1-((4S,5S)-5-methoxymethoxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-amine

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Technology Process of Benzyl-[1-((4S,5S)-5-methoxymethoxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-amine

There total 1 articles about Benzyl-[1-((4S,5S)-5-methoxymethoxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 130675-64-8
(4R,5S)-5-Methoxymethoxymethyl-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde

: 100-46-9
benzylamine

: 130675-65-9
Benzyl-[1-((4S,5S)-5-methoxymethoxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-amine

Guidance literature:: With 4 A molecular sieve; In benzene; for 2h; Ambient temperature;
DOI:10.1248/cpb.38.1601

Reference yield: 51.0%

: 50289-25-3
mixed anhydride of azidoacetic acid and trifluoroacetic anhydride

: 130675-65-9
Benzyl-[1-((4S,5S)-5-methoxymethoxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-amine

: 130675-66-0
(3R,4R)-3-azido-4-<(1S,2S)-1,2-<(isopropylidene)dioxy>-3-(methoxymethoxy)propanyl>-2-azetidinone

Guidance literature:: With TEA; trifluoroacetic anhydride; In dichloromethane; at 0 ℃; for 12h;
DOI:10.1248/cpb.38.1601

Reference yield:

: 130675-65-9
Benzyl-[1-((4S,5S)-5-methoxymethoxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-amine

: 130793-23-6
(4R)-1-benzyl-4-hydroxymethyl-2-azetidinone

Guidance literature:: Multi-step reaction with 9 steps

1: 51 percent / TEA, trifluoroacetic anhydride / CH₂Cl₂ / 12 h / 0 °C

2: 66 percent / p-toluenesulfonic acid monohydrate / methanol / 3 h / 70 °C

3: 1) NaIO₄, 2) NaBH₄ / 1) 2-butanol, water, 2 h, RT, 2) THF, 0 deg C, 1 h

4: 92 percent / N,N-diethylaniline / CH₂Cl₂ / 24 h / Ambient temperature

5: 80 percent / H₂ / 5percent Pd-C / ethyl acetate / 4 h / 760 Torr / Ambient temperature

6: 88 percent / acetic anhydride / 8 h / Ambient temperature

7: 80 percent / POCl₃, 2,6-lutidine / CH₂Cl₂ / Ambient temperature; 1) 4 h, 2) 8 h

8: 95 percent / tributyltin hydride, α,α'-azobis-isobutyronitril / benzene / 0.5 h / 80 °C

9: 86 percent / 10percent aq. HCl / methanol / 3 h / 70 °C

With 2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; sodium periodate; TEA; azobisisobutyronitrile; hydrogen; tri-n-butyl-tin hydride; acetic anhydride; toluene-4-sulfonic acid; N,N-diethylaniline; trifluoroacetic anhydride; trichlorophosphate; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; benzene;
DOI:10.1248/cpb.38.1601