methyl 4-(1-(4-amino-2-chloro-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Base Information

Chemical Name:methyl 4-(1-(4-amino-2-chloro-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate
CAS No.:1562995-91-8
Molecular Formula:C₂₂H₁₆ClFN₄O₃
Molecular Weight:438.845
Hs Code.:

Synonyms:methyl 4-(1-(4-amino-2-chloro-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Suppliers and Price of methyl 4-(1-(4-amino-2-chloro-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 4-(1-(4-amino-2-chloro-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 4-(1-(4-amino-2-chloro-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

There total 8 articles about methyl 4-(1-(4-amino-2-chloro-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1562995-86-1
methyl 4-(1-(4-bromo-2-chloro-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

: 1562995-91-8
methyl 4-(1-(4-amino-2-chloro-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; In tetrahydrofuran; at 80 ℃; for 2h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 1562995-91-8
methyl 4-(1-(4-amino-2-chloro-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-chloro-succinimide; palladium diacetate / N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere

2: oxalyl dichloride / N,N-dimethyl-formamide / 1 h / 20 °C

3: dmap; triethylamine / dichloromethane / 2 h / 20 °C

4: lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 2 h / 80 °C / Inert atmosphere; Microwave irradiation

With dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-chloro-succinimide; oxalyl dichloride; palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 633328-40-2
3-iodo-1H-pyrazolo[4,3-b]pyridine

: 1562995-91-8
methyl 4-(1-(4-amino-2-chloro-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / tetrahydrofuran / 6 h / Reflux

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene; ethanol / 6 h / 120 °C / Inert atmosphere

3: hydrogenchloride / methanol / 14 h / Reflux

4: dmap; triethylamine / dichloromethane / 2 h / 20 °C

5: lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 2 h / 80 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; toluene-4-sulfonic acid; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene; 2: |Suzuki Coupling;