N²-[(2-cyanoethoxy)carbonyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O⁶-[2-(4-nitrophenyl)ethyl]guanosine

Base Information

• Chemical Name: N²-[(2-cyanoethoxy)carbonyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O⁶-[2-(4-nitrophenyl)ethyl]guanosine
• CAS No.: 206662-49-9
• Molecular Formula: C₄₃H₄₁N₇O₁₀
• Molecular Weight: 815.839

Synonyms:N²-[(2-cyanoethoxy)carbonyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O⁶-[2-(4-nitrophenyl)ethyl]guanosine

Chemical Property of N²-[(2-cyanoethoxy)carbonyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O⁶-[2-(4-nitrophenyl)ethyl]guanosine

Chemical Property:

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Technology Process of N²-[(2-cyanoethoxy)carbonyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O⁶-[2-(4-nitrophenyl)ethyl]guanosine

There total 4 articles about N²-[(2-cyanoethoxy)carbonyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O⁶-[2-(4-nitrophenyl)ethyl]guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N2-[(2-cyanoethoxy)carbonyl]-2'-deoxy-O6-[2-(4-nitrophenyl)ethyl]guanosine (206662-47-7) → N2-[(2-cyanoethoxy)carbonyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O6-[2-(4-nitrophenyl)ethyl]guanosine (206662-49-9)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/1522-2675(20001220)83:12<3198::AID-HLCA3198>3.0.CO;2-Q

Reference yield:

2'-deoxy-O6-<2-(4-nitrophenyl)ethyl>guanosine (86137-72-6) → N2-[(2-cyanoethoxy)carbonyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O6-[2-(4-nitrophenyl)ethyl]guanosine (206662-49-9)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / CH₂Cl₂ / 0.5 h / 20 °C

2: CH₂Cl₂ / 4 h / 20 °C

3: 0.836 g / MeOH / 20 h

4: 81 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; methanol; In dichloromethane;

DOI:10.1002/1522-2675(20001220)83:12<3198::AID-HLCA3198>3.0.CO;2-Q

Reference yield:

6-[2-(4-Nitro-phenyl)-ethoxy]-9-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-ylamine → N2-[(2-cyanoethoxy)carbonyl]-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O6-[2-(4-nitrophenyl)ethyl]guanosine (206662-49-9)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 4 h / 20 °C

2: 0.836 g / MeOH / 20 h

3: 81 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

With pyridine; methanol; In dichloromethane;

DOI:10.1002/1522-2675(20001220)83:12<3198::AID-HLCA3198>3.0.CO;2-Q

upstream raw materials:

4,4'-dimethoxytrityl chloride

N²-[(2-cyanoethoxy)carbonyl]-2'-deoxy-O⁶-[2-(4-nitrophenyl)ethyl]guanosine

2'-deoxy-O⁶-<2-(4-nitrophenyl)ethyl>guanosine

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