1'-cyano-1-phenylspiro

Base Information

Chemical Name:1'-cyano-1-phenylspiro
CAS No.:69585-03-1
Molecular Formula:C₁₉H₁₉N₃
Molecular Weight:289.38
Hs Code.:

1'-cyano-1-phenylspiro<indoline-3,4'-piperidine>

Synonyms:1'-cyano-1-phenylspiro

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1'-cyano-1-phenylspiro

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Technology Process of 1'-cyano-1-phenylspiro

There total 5 articles about 1'-cyano-1-phenylspiro which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 506-68-3
bromocyane

: 69585-02-0
1-phenyl-1'-methylspiro[indoline-3,4'-piperidine]

: 69585-03-1
1'-cyano-1-phenylspiro

Guidance literature:: With potassium carbonate; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jm00361a009

Reference yield:

: 326-62-5
2-fluorophenyl acetonitrile

: 69585-03-1
1'-cyano-1-phenylspiro

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMSO, 30 min, 2.) DMSO, 75 deg C, 4 h

2: 92 percent / lithium triethoxyaluminum hydride, lithium aluminum hydride / 1,2-dimethoxy-ethane / 72 h / Heating

3: 70 percent / NaH / dimethylsulfoxide / 4 h / 64 - 70 °C

4: 87 percent / K₂CO₃ / CH₂Cl₂ / 2 h / Ambient temperature

With lithium aluminium tetrahydride; sodium hydride; potassium carbonate; lithium triethoxyaluminum hydride; In 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00361a009

Reference yield:

: 69584-88-9
4-(2-fluorophenyl)-1-methylpiperidine-4-carbonitrile

: 69585-03-1
1'-cyano-1-phenylspiro

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / lithium triethoxyaluminum hydride, lithium aluminum hydride / 1,2-dimethoxy-ethane / 72 h / Heating

2: 70 percent / NaH / dimethylsulfoxide / 4 h / 64 - 70 °C

3: 87 percent / K₂CO₃ / CH₂Cl₂ / 2 h / Ambient temperature

With lithium aluminium tetrahydride; sodium hydride; potassium carbonate; lithium triethoxyaluminum hydride; In 1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00361a009