Technology Process of methanesulfonic acid 2-[3-benzyloxy-5-fluoro-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-benzyl]-5-methylphenyl ester
There total 12 articles about methanesulfonic acid 2-[3-benzyloxy-5-fluoro-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-benzyl]-5-methylphenyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-[2-fluoro-6-hydroxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane;
at 60 ℃;
for 1h;
methanesulfonic acid 2-bromomethyl-5-methylphenyl ester;
With
sodium carbonate;
In
1,2-dimethoxyethane;
at 120 ℃;
for 0.333333h;
Microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: bromine; acetic acid / methanol / 4 h / 0 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C
3.1: triethylamine / dichloromethane / 3 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C
5.1: potassium tert-butylate / tetrahydrofuran / 4 h / 20 °C
6.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 0.33 h / 120 °C / Microwave irradiation
7.1: tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / 1 h / 60 °C
7.2: 0.33 h / 120 °C / Microwave irradiation
With
potassium tert-butylate; bromine; potassium acetate; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 6 h / 20 °C
2.1: tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane / 1 h / 60 °C
2.2: 0.33 h / 120 °C / Microwave irradiation
With
carbon tetrabromide; triphenylphosphine;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; dichloromethane;
