isopropyl 7-{(2R)-2-[(1E)-4,4-difluoro-3-oxo-4-phenylbut-1-enyl]-6-oxopiperidin-1-yl}heptanoate

Base Information

• Chemical Name: isopropyl 7-{(2R)-2-[(1E)-4,4-difluoro-3-oxo-4-phenylbut-1-enyl]-6-oxopiperidin-1-yl}heptanoate
• CAS No.: 768399-83-3
• Molecular Formula: C₂₅H₃₃F₂NO₄
• Molecular Weight: 449.538
• Mol file: 768399-83-3.mol

Synonyms:isopropyl 7-{(2R)-2-[(1E)-4,4-difluoro-3-oxo-4-phenylbut-1-enyl]-6-oxopiperidin-1-yl}heptanoate

Chemical Property of isopropyl 7-{(2R)-2-[(1E)-4,4-difluoro-3-oxo-4-phenylbut-1-enyl]-6-oxopiperidin-1-yl}heptanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isopropyl 7-{(2R)-2-[(1E)-4,4-difluoro-3-oxo-4-phenylbut-1-enyl]-6-oxopiperidin-1-yl}heptanoate

There total 4 articles about isopropyl 7-{(2R)-2-[(1E)-4,4-difluoro-3-oxo-4-phenylbut-1-enyl]-6-oxopiperidin-1-yl}heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H27NO4 (768399-82-2) + dimethyl (3,3-difluoro-2-oxo-3-phenylpropyl)phosphonate (82302-97-4) → isopropyl 7-{(2R)-2-[(1E)-4,4-difluoro-3-oxo-4-phenylbut-1-enyl]-6-oxopiperidin-1-yl}heptanoate (768399-83-3)

Guidance literature:

dimethyl (3,3-difluoro-2-oxo-3-phenylpropyl)phosphonate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

C₁₆H₂₇NO₄; In tetrahydrofuran;

With zinc(II) chloride; In tetrahydrofuran; at 50 ℃;

Reference yield:

C16H27NO4 (768399-82-2) + C11H12F2O4P(1-)*Na(1+) (1055985-86-8) → isopropyl 7-{(2R)-2-[(1E)-4,4-difluoro-3-oxo-4-phenylbut-1-enyl]-6-oxopiperidin-1-yl}heptanoate (768399-83-3)

Guidance literature:

C₁₁H₁₂F₂O₄P^(1-)*Na⁽¹⁺⁾; With zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 0.25h;

C₁₆H₂₇NO₄; In tetrahydrofuran; at 50 ℃; for 50h;

Reference yield:

isopropyl 7-[(2R)-2-(hydroxymethyl)-6-oxopiperidin-1-yl]heptanoate (768399-81-1) + dimethyl (3,3-difluoro-2-oxo-3-phenylpropyl)phosphonate (82302-97-4) → isopropyl 7-{(2R)-2-[(1E)-4,4-difluoro-3-oxo-4-phenylbut-1-enyl]-6-oxopiperidin-1-yl}heptanoate (768399-83-3)

Guidance literature:

isopropyl 7-[(2R)-2-(hydroxymethyl)-6-oxopiperidin-1-yl]heptanoate; With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃; for 0.75h;

dimethyl (3,3-difluoro-2-oxo-3-phenylpropyl)phosphonate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

With zinc(II) chloride; In tetrahydrofuran; at 50 ℃; Product distribution / selectivity;

upstream raw materials:

C₁₆H₂₇NO₄

dimethyl (3,3-difluoro-2-oxo-3-phenylpropyl)phosphonate

C₁₁H₁₂F₂O₄P^(1-)*Na⁽¹⁺⁾

isopropyl 7-[(2R)-2-(hydroxymethyl)-6-oxopiperidin-1-yl]heptanoate

Downstream raw materials:

(S)-tetrahydro-1-butyl-3,3-diphenyl-1H,3H-pyrrolo{2,1-c}{1,3,2}oxazaborole

isopropyl 7-{(2R)-2-[(1E,3R)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-6-oxopiperidin-1-yl}heptanoate