BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Base Information

Chemical Name:BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide
CAS No.:136630-72-3
Molecular Formula:C₄₀H₆₁N₇O₉S
Molecular Weight:816.032
Hs Code.:

BOC-PheΨ<COCH2SO2>Gly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Synonyms:BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

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Technology Process of BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

There total 6 articles about BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 136630-85-8
2-<<(3S)-3-<(tert-butoxycarbonyl)amino>-2-oxo-4-phenylbutyl>sulfonyl>acetic acid

: 136735-33-6
H-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide dihydrochloride

: 136630-72-3
BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 14h; Ambient temperature;
DOI:10.1021/jm00115a016

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 136630-72-3
BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine (NMM) / ethyl acetate / 0.17 h / -10 °C

2: diethyl ether / 3 h / Ambient temperature

3: 47percent aq. HBr / dioxane / 1 h / 0 °C

4: 1.) NaOMe / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 1 h

5: 47 percent / magnesium monoperoxyphthalate / tetrahydrofuran / 1 h / Ambient temperature

6: 42 percent / N-NMM, 1-hydroxybenzotriazole (HOBT), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 14 h / Ambient temperature

With 4-methyl-morpholine; hydrogen bromide; sodium methylate; benzotriazol-1-ol; magnesium monoperoxyphthalate hexahydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00115a016

Reference yield:

: 68709-71-7
tert-butyl 4-bromo-3-oxo-1-phenylbutan-2-ylcarbamate

: 136630-72-3
BOC-PheΨGly-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaOMe / 1.) MeOH, RT, 30 min, 2.) MeOH, RT, 1 h

2: 47 percent / magnesium monoperoxyphthalate / tetrahydrofuran / 1 h / Ambient temperature

3: 42 percent / N-NMM, 1-hydroxybenzotriazole (HOBT), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 14 h / Ambient temperature

With sodium methylate; benzotriazol-1-ol; magnesium monoperoxyphthalate hexahydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00115a016