1-benzyl-4,5,6,7,8,9-hexahydro-1H-cycloocta[d][1,2,3]triazole

Base Information

• Chemical Name: 1-benzyl-4,5,6,7,8,9-hexahydro-1H-cycloocta[d][1,2,3]triazole
• CAS No.: 15922-51-7
• Molecular Formula: C₁₅H₁₉N₃
• Molecular Weight: 241.336
• Mol file: 15922-51-7.mol

Synonyms:1-benzyl-4,5,6,7,8,9-hexahydro-1H-cycloocta[d][1,2,3]triazole

Chemical Property of 1-benzyl-4,5,6,7,8,9-hexahydro-1H-cycloocta[d][1,2,3]triazole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-4,5,6,7,8,9-hexahydro-1H-cycloocta[d][1,2,3]triazole

There total 11 articles about 1-benzyl-4,5,6,7,8,9-hexahydro-1H-cycloocta[d][1,2,3]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(4-tolylsulfinyl)cyclooct-1-en-1-yl triflate + benzyl azide (622-79-7) → 1-benzyl-4,5,6,7,8,9-hexahydro-1H-cycloocta[d][1,2,3]triazole (15922-51-7)

Guidance literature:

With phenylmagnesium bromide; In tetrahydrofuran; at 0 ℃; for 0.25h; Inert atmosphere;

DOI:10.1039/c5cc01784j

Reference yield: 49.0%

4,5,6,7,8,9-hexahydro-cycloocta[1,2,3]selenadiazole (35676-31-4) + benzyl azide (622-79-7) → 1-benzyl-4,5,6,7,8,9-hexahydro-1H-cycloocta[d][1,2,3]triazole (15922-51-7)

Guidance literature:

In dimethyl sulfoxide; at 110 ℃; Solvent; Kinetics;

DOI:10.1039/c6cc01789d

Reference yield:

cyclooctyne (1781-78-8) + benzyl azide (622-79-7) → 1-benzyl-4,5,6,7,8,9-hexahydro-1H-cycloocta[d][1,2,3]triazole (15922-51-7)

Guidance literature:

In tetrahydrofuran; at 25 ℃; Rate constant;

upstream raw materials:

cyclooctyne

benzyl azide

3-azido-propene

1,2-cyclooctene