5-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-methoxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

Base Information

Chemical Name:5-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-methoxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide
CAS No.:1620011-55-3
Molecular Formula:C₂₄H₂₆F₂N₆O₂S
Molecular Weight:500.572
Hs Code.:

Synonyms:5-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-methoxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

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Chemical Property of 5-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-methoxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

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Technology Process of 5-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-methoxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

There total 16 articles about 5-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-methoxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620011-57-5
C₃₄H₄₂F₂N₆O₆S

: 1620011-55-3
5-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-methoxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 - 30 ℃; for 1h;

Reference yield:

: 533-37-9
2,3-cyclopentenopyridine

: 1620011-55-3
5-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-methoxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 14 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 - 30 °C

2.1: trichlorophosphate / 3 h / 120 °C

3.1: sodium methylate / 18 h / 110 °C / Sealed tube

4.1: sulfuric acid; potassium nitrate / 4 h / 0 - 80 °C

5.1: hydrogen bromide; acetic acid / water / 0.67 h / 130 °C / Sealed tube

6.1: trichlorophosphate / 2 h / 110 °C / Sealed tube; Inert atmosphere

7.1: triethylamine / isopropyl alcohol / 0.5 h / 100 °C

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 67 h / 0 - 30 °C

9.1: 1 h / 90 °C / Sealed tube

10.1: iron; acetic acid / water / 0.33 h / 20 - 30 °C

11.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 - 30 °C

12.1: sodium hydroxide / tetrahydrofuran; methanol / 0.42 h / 20 - 30 °C

13.1: sodium hydroxide / tetrahydrofuran / 1 h / 0 °C

13.2: 1 h / 0 °C

14.1: trifluoroacetic acid / dichloromethane / 1 h / 20 - 30 °C

With sulfuric acid; hydrogen bromide; sodium methylate; iron; acetic acid; potassium nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 90685-58-8
6,7-dihydro-5H-cyclopenta[b]pyridine 1-oxide

: 1620011-55-3
5-amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-methoxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide

Guidance literature:: Multi-step reaction with 13 steps

1.1: trichlorophosphate / 3 h / 120 °C

2.1: sodium methylate / 18 h / 110 °C / Sealed tube

3.1: sulfuric acid; potassium nitrate / 4 h / 0 - 80 °C

4.1: hydrogen bromide; acetic acid / water / 0.67 h / 130 °C / Sealed tube

5.1: trichlorophosphate / 2 h / 110 °C / Sealed tube; Inert atmosphere

6.1: triethylamine / isopropyl alcohol / 0.5 h / 100 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 67 h / 0 - 30 °C

8.1: 1 h / 90 °C / Sealed tube

9.1: iron; acetic acid / water / 0.33 h / 20 - 30 °C

10.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 - 30 °C

11.1: sodium hydroxide / tetrahydrofuran; methanol / 0.42 h / 20 - 30 °C

12.1: sodium hydroxide / tetrahydrofuran / 1 h / 0 °C

12.2: 1 h / 0 °C

13.1: trifluoroacetic acid / dichloromethane / 1 h / 20 - 30 °C

With sulfuric acid; hydrogen bromide; sodium methylate; iron; acetic acid; potassium nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;