N-methyl-N-(4-chlorobutyl) N'-(4-carboxyallylmethyl)phenyl phosphorodiamidic chloride

Base Information

• Chemical Name: N-methyl-N-(4-chlorobutyl) N'-(4-carboxyallylmethyl)phenyl phosphorodiamidic chloride
• CAS No.: 898291-05-9
• Molecular Formula: C₁₆H₂₃Cl₂N₂O₃P
• Molecular Weight: 393.25
• Mol file: 898291-05-9.mol

Synonyms:N-methyl-N-(4-chlorobutyl) N'-(4-carboxyallylmethyl)phenyl phosphorodiamidic chloride

Chemical Property of N-methyl-N-(4-chlorobutyl) N'-(4-carboxyallylmethyl)phenyl phosphorodiamidic chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-N-(4-chlorobutyl) N'-(4-carboxyallylmethyl)phenyl phosphorodiamidic chloride

There total 2 articles about N-methyl-N-(4-chlorobutyl) N'-(4-carboxyallylmethyl)phenyl phosphorodiamidic chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

allyl 4-aminophenylacetate (898291-03-7) + N-methyl-N-(4-chloro-n-butyl)amine hydrochloride → N-methyl-N-(4-chlorobutyl) N'-(4-carboxyallylmethyl)phenyl phosphorodiamidic chloride (898291-05-9)

Guidance literature:

allyl 4-aminophenylacetate; With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; at -5 ℃; for 0.166667h;

N-methyl-N-(4-chloro-n-butyl)amine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -5 - 20 ℃; for 3h;

DOI:10.1021/jm060142p

Reference yield:

4-aminophenylacetic acid (1197-55-3) → N-methyl-N-(4-chlorobutyl) N'-(4-carboxyallylmethyl)phenyl phosphorodiamidic chloride (898291-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 51 percent / H₂SO₄ / 2 h / Heating

2.1: diisopropylethylamine; POCl₃ / CH₂Cl₂ / 0.17 h / -5 °C

2.2: 34 percent / diisopropylethylamine / CH₂Cl₂ / 3 h / -5 - 20 °C

With sulfuric acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane;

DOI:10.1021/jm060142p

Reference yield:

N-methyl-N-(4-chlorobutyl) N'-(4-carboxyallylmethyl)phenyl phosphorodiamidic chloride (898291-05-9) + (5-nitrofuran-2-yl)methanol (2493-04-1) → C21H27ClN3O7P

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -20 ℃; for 4h;

DOI:10.1021/jm060142p

upstream raw materials:

allyl 4-aminophenylacetate

4-aminophenylacetic acid

Downstream raw materials:

N-methyl-N-(4-chlorobutyl) O-(5-nitrofuryl-2-methyl) N'-(4-carboxymethyl)phenyl phosphorodiamidate