1-bromo-5-tert-butyl-2,3-di-hex-1-ynyl benzene

Base Information

Chemical Name:1-bromo-5-tert-butyl-2,3-di-hex-1-ynyl benzene
CAS No.:264255-20-1
Molecular Formula:C₂₂H₂₉Br
Molecular Weight:373.376
Hs Code.:

Synonyms:1-bromo-5-tert-butyl-2,3-di-hex-1-ynyl benzene

Suppliers and Price of 1-bromo-5-tert-butyl-2,3-di-hex-1-ynyl benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-bromo-5-tert-butyl-2,3-di-hex-1-ynyl benzene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-bromo-5-tert-butyl-2,3-di-hex-1-ynyl benzene

There total 2 articles about 1-bromo-5-tert-butyl-2,3-di-hex-1-ynyl benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 693-02-7
hex-1-yne

: 264255-18-7
1-bromo-5-tert-butyl-2,3-diiodo-benzene

: 264255-20-1
1-bromo-5-tert-butyl-2,3-di-hex-1-ynyl benzene

Guidance literature:: With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 85 ℃; for 36h;
DOI:10.1021/ol005615f

Reference yield:

: 191983-33-2
2-bromo-4-tert-butyl-6-iodo-aniline

: 264255-20-1
1-bromo-5-tert-butyl-2,3-di-hex-1-ynyl benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: conc. H₂SO₄ / acetic acid / 0.5 h / 20 °C

1.2: NaNO₂ / acetic acid; H₂O / 1.5 h / 0 °C

1.3: KI; I₂ / acetic acid; H₂O / 24 h

2.1: 40 percent / copper(I) iodide; piperidine; [(PPh₃)2PdCl₂] / 36 h / 85 °C

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; In acetic acid; 1.1: Substitution / 1.2: Nitrosation / 1.3: Iodination / 2.1: Substitution;
DOI:10.1021/ol005615f

Reference yield:

: 264255-20-1
1-bromo-5-tert-butyl-2,3-di-hex-1-ynyl benzene

: 3-tert-butyl-1(5-tert-butyl-2,3-di-hex-1-ynylphenyl)naphthalene

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; various solvent(s) / 0.33 h / -78 °C

1.2: ZnCl₂ / tetrahydrofuran; various solvent(s); diethyl ether / -78 - 20 °C

1.3: 35 percent / bis(triphenylphosphine) palladium(II) chloride / tetrahydrofuran; various solvent(s); diethyl ether / 72 h / 65 °C

2.1: NaH / methanol; tetrahydrofuran / 0.5 h

3.1: 20 percent / 1,4-cyclohexadiene / benzene / 2 h / 170 °C

With n-butyllithium; cyclohexa-1,4-diene; sodium hydride; In tetrahydrofuran; methanol; benzene; 1.1: Metallation / 1.2: Substitution / 1.3: coupling / 2.1: desilylation / 3.1: Cyclization;
DOI:10.1021/ol005615f