8-Chloro-2-(chloromethyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

Base Information

Chemical Name:8-Chloro-2-(chloromethyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine
CAS No.:182181-31-3
Molecular Formula:C₉H₅Cl₂F₃N₂
Molecular Weight:269.053
Hs Code.:
DSSTox Substance ID:DTXSID10598423
Wikidata:Q82494180
Mol file:182181-31-3.mol

Synonyms:182181-31-3;8-chloro-2-(chloromethyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine;8-CHLORO-2-CHLOROMETHYL-6-TRIFLUOROMETHYL-IMIDAZO[1,2-A]PYRIDINE;Imidazo[1,2-a]pyridine, 8-chloro-2-(chloromethyl)-6-(trifluoromethyl)-;C9H5Cl2F3N2;1026551-28-9;SCHEMBL8182170;DTXSID10598423;AKOS022279727;AB28991;GS-1041;DB-359972;CS-0448650;8-Chloro-2-chloromethyl-6-trifluoromethylimidazo[1,2-a]pyridine;8-chloro-2-(chloromethyl)-6-trifluoromethylimidazo[1,2-alpha]pyridine

Suppliers and Price of 8-Chloro-2-(chloromethyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
8-Chloro-2-chloromethyl-6-trifluoromethyl-imidazo[1,2-a]pyridine 96%
500mg
$ 840.00

Total 6 raw suppliers

Chemical Property of 8-Chloro-2-(chloromethyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

Chemical Property:

PSA：17.30000
LogP:3.74530
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:267.9781880
Heavy Atom Count:16
Complexity:262

Purity/Quality:

97% ^*data from raw suppliers

8-Chloro-2-chloromethyl-6-trifluoromethyl-imidazo[1,2-a]pyridine 96% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C2=NC(=CN2C=C1C(F)(F)F)CCl)Cl

Technology Process of 8-Chloro-2-(chloromethyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

There total 2 articles about 8-Chloro-2-(chloromethyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)methanol

: 182181-31-3
8-chloro-2-(chloromethyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

Guidance literature:: With thionyl chloride; In 1,2-dichloro-ethane; at 45 ℃; for 3h;

Reference yield:

: 353258-31-8
8-chloro-6-(trifluoromethyl)imidazo[1,2,a]pyridine-2-carboxylic acid ethyl ester

: 182181-31-3
8-chloro-2-(chloromethyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 2 h / -40 - 0 °C

2: thionyl chloride / 1,2-dichloro-ethane / 3 h / 45 °C

With thionyl chloride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; 1,2-dichloro-ethane;