Benzyl-((S)-1-{benzyl-[(S)-1-(benzyl-trimethylsilanylmethyl-carbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:Benzyl-((S)-1-{benzyl-[(S)-1-(benzyl-trimethylsilanylmethyl-carbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester
CAS No.:607741-40-2
Molecular Formula:C₃₆H₄₉N₃O₄Si
Molecular Weight:615.888
Hs Code.:

Synonyms:Benzyl-((S)-1-{benzyl-[(S)-1-(benzyl-trimethylsilanylmethyl-carbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

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Chemical Property of Benzyl-((S)-1-{benzyl-[(S)-1-(benzyl-trimethylsilanylmethyl-carbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Benzyl-((S)-1-{benzyl-[(S)-1-(benzyl-trimethylsilanylmethyl-carbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

There total 5 articles about Benzyl-((S)-1-{benzyl-[(S)-1-(benzyl-trimethylsilanylmethyl-carbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 159999-80-1
N-benzyl-N-Boc-L-alanine

: 607741-21-9
N-benzyl-2-benzylamino-N-trimethylsilanylmethyl-propionamide

: 607741-40-2
Benzyl-((S)-1-{benzyl-[(S)-1-(benzyl-trimethylsilanylmethyl-carbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; at 25 ℃; for 4h;
DOI:10.1021/ja030297b

Reference yield:

: 7585-47-9,40297-69-6,65491-01-2
N-benzyl-(S)-alanine

: 607741-40-2
Benzyl-((S)-1-{benzyl-[(S)-1-(benzyl-trimethylsilanylmethyl-carbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / Et₃N / H₂O; dioxane / 4 h / 25 °C

2: 72 percent / 1-hydroxybenzotriazole; 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / 6 h / 20 °C

3: 96 percent / TFA / CH₂Cl₂ / 4 h / 25 °C

4: 79 percent / EEDQ / CH₂Cl₂ / 4 h / 25 °C

With benzotriazol-1-ol; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/ja030297b

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 607741-40-2
Benzyl-((S)-1-{benzyl-[(S)-1-(benzyl-trimethylsilanylmethyl-carbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / Et₃N / H₂O; dioxane / 4 h / 25 °C

2: 79 percent / EEDQ / CH₂Cl₂ / 4 h / 25 °C

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/ja030297b