Technology Process of Phenol, 4,5-difluoro-2,3-dimethyl- (9CI)
There total 2 articles about Phenol, 4,5-difluoro-2,3-dimethyl- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Selectfluor;
In
methanol;
for 2.5h;
Heating;
DOI:10.1021/jm9603633
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) 48percent fluoboric acid, 4A molecular sieves, 2.) isoamyl nitrite / 1.) ether, RT, 1 h, 2.) ether, a) 0 deg C, 1 h, b) from 0 deg C to RT, 0.5 h, c) reflux, 3 h
2: 14 percent / 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo<2.2.2>octane bis(tetrafluoroborate) / methanol / 2.5 h / Heating
With
tetrafluoroboric acid; 4 A molecular sieve; Selectfluor; isopentyl nitrite;
In
methanol;
DOI:10.1021/jm9603633
- Guidance literature:
-
Multi-step reaction with 8 steps
1: K2CO3 / dimethylformamide / Ambient temperature
2: N,N-diethylaniline / 4 h / 200 °C
3: imidazole / dimethylformamide
4: 1.) pyridine, ozonized O2, 2.) Me3S / 1.) CH2Cl2, MeOH, -78 deg C, 2.) CH2Cl2, MeOH, RT, overnight
5: tetrahydrofuran / -78 °C
6: pivalic acid / Heating
7: 1.0 M tetrabutylammonium fluoride / tetrahydrofuran / 0.17 h
8: K2CO3 / acetone / 20 h
With
pyridine; 1H-imidazole; ozone-containing oxygen; trimethylsulfonium; tetrabutyl ammonium fluoride; potassium carbonate; N,N-diethylaniline; Trimethylacetic acid;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm9603633
