Chemical Property of 2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate
Chemical Property:
- Vapor Pressure:1.67E-11mmHg at 25°C
- Boiling Point:534.6°Cat760mmHg
- Flash Point:277.1°C
- PSA:192.97000
- Density:g/cm3
- LogP:5.25100
- Storage Temp.:Store at RT
- Solubility.:Soluble in DMSO (up to 50 mg/ml).
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:8
- Rotatable Bond Count:7
- Exact Mass:427.08717775
- Heavy Atom Count:28
- Complexity:479
- Purity/Quality:
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99%, *data from raw suppliers
KB-R7943 mesylate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CS(=O)(=O)O.C1=CC(=CC=C1CCSC(=N)N)OCC2=CC=C(C=C2)[N+](=O)[O-]
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Description
KB-R7943 (182004-65-5) is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50‘s = 1.2-2.4 μM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7 μM in cultured rat forebrain2). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) Ki = 5.5 μM.3 Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 μM) and block NMDA receptors (IC50 = 13.4 μM).4
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Uses
KB-R7943 Mesylate is a selective inhibitor of the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1.