4-bromo-1-(ethoxymethyl)-2-(α-(2,2,2-trifluoroethoxy)-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

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Chemical Name:4-bromo-1-(ethoxymethyl)-2-(α-(2,2,2-trifluoroethoxy)-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile
CAS No.:1614231-83-2
Molecular Formula:C₁₈H₁₄BrClF₆N₂O₂
Molecular Weight:519.669
Hs Code.:

Synonyms:4-bromo-1-(ethoxymethyl)-2-(α-(2,2,2-trifluoroethoxy)-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

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Chemical Property of 4-bromo-1-(ethoxymethyl)-2-(α-(2,2,2-trifluoroethoxy)-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

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Technology Process of 4-bromo-1-(ethoxymethyl)-2-(α-(2,2,2-trifluoroethoxy)-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

There total 5 articles about 4-bromo-1-(ethoxymethyl)-2-(α-(2,2,2-trifluoroethoxy)-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1614231-76-3
4-bromo-2-(α-(2,2,2-trifluoroethoxy)-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

: 3188-13-4
ethyl chloromethyl ether

: 1614231-83-2
4-bromo-1-(ethoxymethyl)-2-(α-(2,2,2-trifluoroethoxy)-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

Guidance literature:: 4-bromo-2-(α-(2,2,2-trifluoroethoxy)-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

ethyl chloromethyl ether; In tetrahydrofuran; for 2.5h; Reflux;
DOI:10.1021/jf501377t DOI:10.1021/jf501377t

Reference yield:

: 1614231-61-6
C₁₃H₇BrClF₃N₂

: 1614231-83-2
4-bromo-1-(ethoxymethyl)-2-(α-(2,2,2-trifluoroethoxy)-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 12 h / 20 °C / Reflux

2.1: sodium hydride / tetrahydrofuran / 1.5 h / Reflux

2.2: 3 h / Reflux

3.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

3.2: 2.5 h / Reflux

With sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jf501377t

Reference yield:

: 1614231-66-1
4-bromo-2-(4-chlorobenzoyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

: 1614231-83-2
4-bromo-1-(ethoxymethyl)-2-(α-(2,2,2-trifluoroethoxy)-4-chlorobenzyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / tetrahydrofuran / 12 h / 20 °C

2.1: sulfuryl dichloride / dichloromethane / 8 h / Reflux

3.1: sodium hydride / tetrahydrofuran / 1.5 h / Reflux

3.2: 3 h / Reflux

4.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

4.2: 2.5 h / Reflux

With sodium tetrahydroborate; sulfuryl dichloride; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jf501377t