(R)-tert-butyl 1-(2-(4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

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Chemical Name:(R)-tert-butyl 1-(2-(4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate
CAS No.:1350917-96-2
Molecular Formula:C₃₆H₄₈FN₇O₄Si
Molecular Weight:689.906
Hs Code.:

(R)-tert-butyl 1-(2-(4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

Synonyms:(R)-tert-butyl 1-(2-(4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

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Chemical Property of (R)-tert-butyl 1-(2-(4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

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Technology Process of (R)-tert-butyl 1-(2-(4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

There total 8 articles about (R)-tert-butyl 1-(2-(4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1350917-80-4
C₁₆H₂₄FN₃O₂

: 1350917-95-1
lithium 4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxylate

: 1350917-96-2
(R)-tert-butyl 1-(2-(4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1350917-96-2
(R)-tert-butyl 1-(2-(4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

2: N-Bromosuccinimide / dichloromethane; N,N-dimethyl-formamide / 20 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 1 h / 110 °C / Inert atmosphere; Microwave irradiation

4: water; lithium hydroxide / 1,4-dioxane / 20 °C

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 50 °C

With 4-methyl-morpholine; N-Bromosuccinimide; water; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 6921-22-8
1,2-difluoro-3-nitrobenzene

: 1350917-96-2
(R)-tert-butyl 1-(2-(4-(1-benzyl-1H-pyrazol-4-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-2-carboxamido)-6-fluorophenyl)piperidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 80 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 50 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide; acetonitrile;