Technology Process of 1-tetrahydropyranyloxy-2,13-octadecadiyne
There total 1 articles about 1-tetrahydropyranyloxy-2,13-octadecadiyne which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 3 h
2.1: n-butyllithium / tetrahydrofuran
2.2: tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / 20 °C
3.1: p-toluenesulfonic acid / ethanol / 3 h / Heating
4.1: iodine; triphenylphosphine; imidazole / diethyl ether; acetonitrile / 1 h / 0 °C
5.1: n-butyllithium / tetrahydrofuran
5.2: 67 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / 1 h / 20 °C
With
1H-imidazole; n-butyllithium; iodine; toluene-4-sulfonic acid; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; ethanol; acetonitrile;
DOI:10.1271/bbb.70.508
- Guidance literature:
-
Multi-step reaction with 3 steps
1: aq. PTSA / methanol / 0.75 h / Heating
2: 99 percent / LiAlH4 / tetrahydrofuran / Ambient temperature
3: 98 percent / H2, quinoline / Pd/BaSO4 / hexane / 4 h / Ambient temperature
With
quinoline; lithium aluminium tetrahydride; hydrogen; toluene-4-sulfonic acid;
Pd-BaSO4;
In
tetrahydrofuran; methanol; hexane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: aq. PTSA / methanol / 0.75 h / Heating
2: 99 percent / LiAlH4 / tetrahydrofuran / Ambient temperature
3: 98 percent / H2, quinoline / Pd/BaSO4 / hexane / 4 h / Ambient temperature
4: 98 percent / AcONa / 5 h / Ambient temperature
With
quinoline; lithium aluminium tetrahydride; hydrogen; sodium acetate; toluene-4-sulfonic acid;
Pd-BaSO4;
In
tetrahydrofuran; methanol; hexane;
