(3S,5R)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-3-methyl-3-trimethylsilanyloxy-dihydro-furan-2-one

Base Information

Chemical Name:(3S,5R)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-3-methyl-3-trimethylsilanyloxy-dihydro-furan-2-one
CAS No.:87640-65-1
Molecular Formula:C₄₂H₇₆O₅Si₃
Molecular Weight:745.319
Hs Code.:

(3S,5R)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-3-methyl-3-trimethylsilanyloxy-dihydro-furan-2-one

Synonyms:(3S,5R)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-3-methyl-3-trimethylsilanyloxy-dihydro-furan-2-one

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Chemical Property of (3S,5R)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-3-methyl-3-trimethylsilanyloxy-dihydro-furan-2-one

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Technology Process of (3S,5R)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-3-methyl-3-trimethylsilanyloxy-dihydro-furan-2-one

There total 18 articles about (3S,5R)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-3-methyl-3-trimethylsilanyloxy-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: C₃₃H₅₀LiO₃PSi₂

: 83685-54-5
(3R,5S)-3-Methyl-5-[(R)-2-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-inden-1-yl)-propyl]-3-trimethylsilanyloxy-dihydro-furan-2-one

: 87640-65-1
(3R,5S)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-3-methyl-3-trimethylsilanyloxy-dihydro-furan-2-one

Guidance literature:: In tetrahydrofuran; at -78 ℃;
DOI:10.1021/jo00171a068

Reference yield: 90.0%

: C₃₃H₅₀LiO₃PSi₂

: 87680-16-8
(3S,5R)-3-Methyl-5-[(R)-2-((1R,3aR,7aR)-7a-methyl-4-oxo-octahydro-inden-1-yl)-propyl]-3-trimethylsilanyloxy-dihydro-furan-2-one

: 87640-65-1
(3S,5R)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-3-methyl-3-trimethylsilanyloxy-dihydro-furan-2-one

Guidance literature:: In tetrahydrofuran; at -78 ℃;
DOI:10.1021/jo00171a068

Reference yield:

: 81506-36-7
Acetic acid (3aR,4R,7aS)-1-eth-(Z)-ylidene-7a-methyl-octahydro-inden-4-yl ester

: 87640-65-1
(3R,5S)-5-((R)-2-{(1R,3aS,7aR)-4-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-propyl)-3-methyl-3-trimethylsilanyloxy-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: ethylaluminum dichloride / CH₂Cl₂ / 25 h / 0 deg C to room temp.

2: 91 percent / diisobutylaluminum hydride / tetrahydrofuran / 0 deg C to room temp.

3: 84 percent / KO-t-Bu / 2-methyl-propan-2-ol / Ambient temperature

4: 72 percent / H₂ / 5percent Pt on C / ethyl acetate

5: 99 percent / ethyl acetate / Ambient temperature

6: tetrahydrofuran / -78 deg C to room temp.

7: 2,2'-bipyridinium chlorochromate / CH₂Cl₂

9: 90 percent / tetrahydrofuran / -78 °C

With potassium tert-butylate; hydrogen; ethylaluminum dichloride; diisobutylaluminium hydride; 2,2'-bipyridinium chlorochromate; platinum on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/jo00171a068