(2S)-2-({2-amino-5-[2-methoxy-4-(piperazin-1-ylmethyl)benzyl]-6-methylpyrimidin-4-yl}amino)pentan-1-ol

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Chemical Name:(2S)-2-({2-amino-5-[2-methoxy-4-(piperazin-1-ylmethyl)benzyl]-6-methylpyrimidin-4-yl}amino)pentan-1-ol
CAS No.:1376606-77-7
Molecular Formula:C₂₃H₃₆N₆O₂
Molecular Weight:428.578
Hs Code.:

Synonyms:(2S)-2-({2-amino-5-[2-methoxy-4-(piperazin-1-ylmethyl)benzyl]-6-methylpyrimidin-4-yl}amino)pentan-1-ol

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Chemical Property of (2S)-2-({2-amino-5-[2-methoxy-4-(piperazin-1-ylmethyl)benzyl]-6-methylpyrimidin-4-yl}amino)pentan-1-ol

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Technology Process of (2S)-2-({2-amino-5-[2-methoxy-4-(piperazin-1-ylmethyl)benzyl]-6-methylpyrimidin-4-yl}amino)pentan-1-ol

There total 8 articles about (2S)-2-({2-amino-5-[2-methoxy-4-(piperazin-1-ylmethyl)benzyl]-6-methylpyrimidin-4-yl}amino)pentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-85-0
piperazine

: 1376514-28-1
4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxybenzaldehyde

: 1376606-77-7
(2S)-2-({2-amino-5-[2-methoxy-4-(piperazin-1-ylmethyl)benzyl]-6-methylpyrimidin-4-yl}amino)pentan-1-ol

Guidance literature:: piperazine; 4-[(2-amino-4-{[(2S)-1-hydroxypentan-2-yl]amino}-6-methylpyrimidin-5-yl)-methyl]-3-methoxybenzaldehyde; In methanol; for 2h; Reflux;

With methanol; sodium tetrahydroborate; at 20 ℃; for 1h;

Reference yield:

: 70264-94-7
methyl 4-(bromomethyl)-3-methoxybenzoate

: 1376606-77-7
(2S)-2-({2-amino-5-[2-methoxy-4-(piperazin-1-ylmethyl)benzyl]-6-methylpyrimidin-4-yl}amino)pentan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 15 h / 70 °C

1.3: 0.5 h / Cooling with ice

2.1: ethanol / 15 h / 80 °C

3.1: trichlorophosphate / 15 h / 100 °C

3.2: 2 h / 50 °C / pH 7

4.1: 1,4-dioxane / 9 h / 170 °C / Microwave irradiation

5.1: water; lithium hydroxide / tetrahydrofuran / 6 h / 120 °C / Microwave irradiation

5.2: pH 7

6.1: borane-THF / 2 h / 80 °C

6.2: 1 h / 80 °C

7.1: manganese(IV) oxide / dichloromethane / 3 h / 20 °C

8.1: methanol / 2 h / Reflux

8.2: 1 h / 20 °C

With manganese(IV) oxide; borane-THF; water; sodium hydride; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; mineral oil;

Reference yield:

: 1158804-08-0
methyl 3-methoxy-4-(2-(ethoxycarbonyl)-3-oxobutyl)benzoate

: 1376606-77-7
(2S)-2-({2-amino-5-[2-methoxy-4-(piperazin-1-ylmethyl)benzyl]-6-methylpyrimidin-4-yl}amino)pentan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: ethanol / 15 h / 80 °C

2.1: trichlorophosphate / 15 h / 100 °C

2.2: 2 h / 50 °C / pH 7

3.1: 1,4-dioxane / 9 h / 170 °C / Microwave irradiation

4.1: water; lithium hydroxide / tetrahydrofuran / 6 h / 120 °C / Microwave irradiation

4.2: pH 7

5.1: borane-THF / 2 h / 80 °C

5.2: 1 h / 80 °C

6.1: manganese(IV) oxide / dichloromethane / 3 h / 20 °C

7.1: methanol / 2 h / Reflux

7.2: 1 h / 20 °C

With manganese(IV) oxide; borane-THF; water; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane;