(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(2-pyrazol-1-yl-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(2-pyrazol-1-yl-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1026226-35-6
Molecular Formula:C₃₂H₃₆N₄O₇
Molecular Weight:588.66
Hs Code.:

(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(2-pyrazol-1-yl-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms:(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(2-pyrazol-1-yl-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(2-pyrazol-1-yl-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(2-pyrazol-1-yl-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 7 articles about (2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(2-pyrazol-1-yl-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1485-00-3,22568-48-5
5-((E)-2-nitroethenyl)-1,3-benzodioxole

: 1026226-35-6
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(2-pyrazol-1-yl-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: t-BuOK / tetrahydrofuran / 2 h / Ambient temperature

2: H₂ / Raney nickel / ethyl acetate / 3040 Torr

3: 1.) NaBH₃CN, HCl, 2.) DBU / 1.) THF, EtOH, 40 min, 2.) MeCN, reflux, overnight

4: Et₃N / CH₂Cl₂

5: 6N aq. NaOH / ethanol

6: EDCl / dimethylformamide

7: tetrahydrofuran

With hydrogenchloride; sodium hydroxide; potassium tert-butylate; hydrogen; sodium cyanoborohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; nickel; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm980217s

Reference yield:

: 2-(1-Benzo[1,3]dioxol-5-yl-2-nitro-ethyl)-3-oxo-5-pyridin-2-yl-pentanoic acid ethyl ester

: 1026226-35-6
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(2-pyrazol-1-yl-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Raney nickel / ethyl acetate / 3040 Torr

2: 1.) NaBH₃CN, HCl, 2.) DBU / 1.) THF, EtOH, 40 min, 2.) MeCN, reflux, overnight

3: Et₃N / CH₂Cl₂

4: 6N aq. NaOH / ethanol

5: EDCl / dimethylformamide

6: tetrahydrofuran

With hydrogenchloride; sodium hydroxide; hydrogen; sodium cyanoborohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; nickel; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm980217s

Reference yield:

: (2R,3S,4R)-4-Benzo[1,3]dioxol-5-yl-2-(2-pyridin-2-yl-ethyl)-pyrrolidine-3-carboxylic acid ethyl ester

: 1026226-35-6
(2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-3-((S)-4-benzyl-2-oxo-oxazolidine-3-carbonyl)-2-(2-pyrazol-1-yl-ethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂

2: 6N aq. NaOH / ethanol

3: EDCl / dimethylformamide

4: tetrahydrofuran

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980217s