4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester

Base Information

• Chemical Name: 4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester
• CAS No.: 181629-57-2
• Molecular Formula: C30H40 N2 O6
• Molecular Weight: 524.65
• Mol file: 181629-57-2.mol

Synonyms:4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester;4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid t-Butyl Ester

Chemical Property of 4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester

Chemical Property:

• Refractive Index: 1.569
• PSA: 85.38000
• LogP: 5.87630
• Solubility.: Dichloromethane, Diethyl Ether, Methanol

Purity/Quality:

97% ^*data from raw suppliers

4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylicAcidt-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid t-Butyl Ester (cas# 181629-57-2) is a compound useful in organic synthesis.

Technology Process of 4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester

There total 3 articles about 4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl chloroformate (501-53-1,94274-21-2) + 4-(4-Benzyloxycarbonyl-butylamino)-piperidine-1-carboxylic acid tert-butyl ester; compound with toluene-4-sulfonic acid → 4-[Benzyloxycarbonyl-(4-benzyloxycarbonyl-butyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester (181629-57-2)

Guidance literature:

With sodium hydrogencarbonate; In water; ethyl acetate; at 25 ℃; for 4h;

DOI:10.1016/0040-4039(96)01387-1

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4-[Benzyloxycarbonyl-(4-benzyloxycarbonyl-butyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester (181629-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / NaBH(OAc)3 / acetic acid; CH₂Cl₂ / 3 h / 25 °C

2: 100 percent / NaHCO₃ / ethyl acetate; H₂O / 4 h / 25 °C

With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; In dichloromethane; water; acetic acid; ethyl acetate;

DOI:10.1016/0040-4039(96)01387-1

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 4-[Benzyloxycarbonyl-(4-benzyloxycarbonyl-butyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester (181629-57-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / tosylchloride / 2.5 h / 80 °C

2: 67 percent / NaBH(OAc)3 / acetic acid; CH₂Cl₂ / 3 h / 25 °C

3: 100 percent / NaHCO₃ / ethyl acetate; H₂O / 4 h / 25 °C

With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; p-toluenesulfonyl chloride; In dichloromethane; water; acetic acid; ethyl acetate;

DOI:10.1016/0040-4039(96)01387-1

upstream raw materials:

benzyl chloroformate

N-tert-butyloxycarbonylpiperidin-4-one

benzyl alcohol

Downstream raw materials:

4-[Benzyloxycarbonyl-(4-benzyloxycarbonyl-butyl)-amino]-piperidine-1-carboxylic acid (S)-4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester

5-[Benzyloxycarbonyl-(1-chlorocarbonyl-piperidin-4-yl)-amino]-pentanoic acid benzyl ester

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