Technology Process of 8-(3,4-dichlorophenyl)-3-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine
There total 7 articles about 8-(3,4-dichlorophenyl)-3-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-[4-chloro-1-(3,4-dichlorophenyl)butyl]-5-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-y1)phenyl]-1,3,4-oxadiazole;
With
sodium azide;
In
dimethyl sulfoxide;
at 70 ℃;
for 5h;
With
triphenylphosphine;
In
tetrahydrofuran; water;
at 60 ℃;
for 3h;
With
acetic acid;
for 1.5h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: johnphos; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 4 h / 120 °C
1.2: 2 h / Reflux
2.1: triethylamine; diethyl cyanophosphonate; t-butoxycarbonylhydrazine / N,N-dimethyl-formamide / 3 h / 20 °C
2.2: 24 h / 20 °C
2.3: 2 h / 20 °C
3.1: trichlorophosphate / 5 h / Reflux
4.1: sodium azide / dimethyl sulfoxide / 5 h / 70 °C
4.2: 3 h / 60 °C
4.3: 1.5 h / Reflux
With
sodium azide; t-butoxycarbonylhydrazine; diethyl cyanophosphonate; triethylamine; trichlorophosphate;
tris-(dibenzylideneacetone)dipalladium(0); johnphos;
In
dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methanol / 0.5 h / 20 °C
1.2: 16 h / 100 °C
2.1: johnphos; tris-(dibenzylideneacetone)dipalladium(0) / N,N-dimethyl-formamide / 4 h / 120 °C
2.2: 2 h / Reflux
3.1: triethylamine; diethyl cyanophosphonate; t-butoxycarbonylhydrazine / N,N-dimethyl-formamide / 3 h / 20 °C
3.2: 24 h / 20 °C
3.3: 2 h / 20 °C
4.1: trichlorophosphate / 5 h / Reflux
5.1: sodium azide / dimethyl sulfoxide / 5 h / 70 °C
5.2: 3 h / 60 °C
5.3: 1.5 h / Reflux
With
sodium azide; t-butoxycarbonylhydrazine; diethyl cyanophosphonate; triethylamine; trichlorophosphate;
tris-(dibenzylideneacetone)dipalladium(0); johnphos;
In
methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
![2-[4-chloro-1-(3,4-dichlorophenyl)butyl]-5-[3-methoxy-4-(3-methyl-1H-1,2,4-triazol-1-y1)phenyl]-1,3,4-oxadiazole](/Databaselist/images/loading.webp)
