N,2-dimethyl-6-(4-methylpiperazin-1-yl)-N-(3-nitrophenyl)pyrimidin-4-amine

Base Information

Chemical Name:N,2-dimethyl-6-(4-methylpiperazin-1-yl)-N-(3-nitrophenyl)pyrimidin-4-amine
CAS No.:1402747-90-3
Molecular Formula:C₁₇H₂₂N₆O₂
Molecular Weight:342.401
Hs Code.:

Synonyms:N,2-dimethyl-6-(4-methylpiperazin-1-yl)-N-(3-nitrophenyl)pyrimidin-4-amine

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Chemical Property of N,2-dimethyl-6-(4-methylpiperazin-1-yl)-N-(3-nitrophenyl)pyrimidin-4-amine

Chemical Property:

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Technology Process of N,2-dimethyl-6-(4-methylpiperazin-1-yl)-N-(3-nitrophenyl)pyrimidin-4-amine

There total 3 articles about N,2-dimethyl-6-(4-methylpiperazin-1-yl)-N-(3-nitrophenyl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 109-01-3
1-methyl-piperazine

: 1402747-86-7
6-chloro-N,2-dimethyl-N-(3-nitrophenyl)pyrimidin-4-amine

: 1402747-90-3
N,2-dimethyl-6-(4-methylpiperazin-1-yl)-N-(3-nitrophenyl)pyrimidin-4-amine

Guidance literature:: In dimethyl sulfoxide; at 140 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1111/cbdd.12198

Reference yield:

: 99-09-2
3-nitro-aniline

: 1402747-90-3
N,2-dimethyl-6-(4-methylpiperazin-1-yl)-N-(3-nitrophenyl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / acetone; water / 2 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide

3: dimethyl sulfoxide / 0.33 h / 40 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1402747-70-9
6-chloro-2-methyl-N-(3-nitrophenyl)pyrimidin-4-amine hydrochloride

: 1402747-90-3
N,2-dimethyl-6-(4-methylpiperazin-1-yl)-N-(3-nitrophenyl)pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: dimethyl sulfoxide / 0.33 h / 40 °C / Inert atmosphere

With potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;