4-methyl-2-(2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-acetamido)thiophene-3-carboxamide

Base Information

Chemical Name:4-methyl-2-(2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-acetamido)thiophene-3-carboxamide
CAS No.:1239461-50-7
Molecular Formula:C₂₂H₂₉N₃O₃S
Molecular Weight:415.557
Hs Code.:

Synonyms:4-methyl-2-(2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-acetamido)thiophene-3-carboxamide

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Chemical Property of 4-methyl-2-(2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-acetamido)thiophene-3-carboxamide

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Technology Process of 4-methyl-2-(2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-acetamido)thiophene-3-carboxamide

There total 7 articles about 4-methyl-2-(2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-acetamido)thiophene-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4651-97-2
2-amino-4-methylthiophene-3-carboxylic acid amide

: 1116338-56-7
2-(4-(3-(piperidin-1-yl)propoxy)phenyl)acetic acid

: 1239461-50-7
4-methyl-2-(2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-acetamido)thiophene-3-carboxamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1239461-49-4
methyl 2-(4-(3-(piperidin-1-yl)propoxy)phenyl)acetate

: 1239461-50-7
4-methyl-2-(2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-acetamido)thiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; acetic acid / Reflux

2: pyridine; trichlorophosphate / 0.08 h / 0 °C

3: ammonium hydroxide; ammonium chloride / water

With pyridine; hydrogenchloride; ammonium hydroxide; ammonium chloride; acetic acid; trichlorophosphate; In water;
DOI:10.1016/j.bmcl.2011.01.046

Reference yield:

: 4651-98-3
2-amino-4-methylthiophene-3-carboxylic acid methyl ester

: 1239461-50-7
4-methyl-2-(2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-acetamido)thiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; trichlorophosphate / 0.08 h / 0 °C

2: ammonium hydroxide; ammonium chloride / water

With pyridine; ammonium hydroxide; ammonium chloride; trichlorophosphate; In water;
DOI:10.1016/j.bmcl.2011.01.046