(1R,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-(hydroxymethyl)cyclopropanecarboxamide

Base Information

Chemical Name:(1R,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-(hydroxymethyl)cyclopropanecarboxamide
CAS No.:1365990-88-0
Molecular Formula:C₁₇H₁₃Cl₂N₃O₂S
Molecular Weight:394.281
Hs Code.:

Synonyms:(1R,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-(hydroxymethyl)cyclopropanecarboxamide

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Chemical Property of (1R,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-(hydroxymethyl)cyclopropanecarboxamide

Chemical Property:

Purity/Quality:

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Technology Process of (1R,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-(hydroxymethyl)cyclopropanecarboxamide

There total 13 articles about (1R,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-(hydroxymethyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365993-07-2
3-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-3-aza-bicyclo[3.1.0]hexane-2,4-dione

: 1365990-88-0
(1R,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-(hydroxymethyl)cyclopropanecarboxamide

: 1365990-89-1
(1S,2R)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-(hydroxymethyl)cyclopropanecarboxamide

Guidance literature:: With sodium tetrahydroborate; water; In isopropyl alcohol; at 20 ℃; for 1h;

Reference yield:

: 1365991-84-9
(E)-3-(2-(2,6-dichlorophenyl)thiazol-4-yl)acrylic acid

: 1365990-88-0
(1R,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-(hydroxymethyl)cyclopropanecarboxamide

: 1365990-89-1
(1S,2R)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-(hydroxymethyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2: sodium azide / 1,4-dioxane; water; acetone / 0 °C

3: 1,4-dioxane; diphenyl ether-biphenyl eutectic / 1.25 h / 230 °C

4: phosphorus(V) oxybromide / acetonitrile / 2 h / 100 °C

5: sodium t-butanolate; Benzophenone imine / tris-(dibenzylideneacetone)dipalladium(0); racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl / toluene / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

6: 1,4-dioxane / 2 h / 90 °C

7: water; sodium tetrahydroborate / isopropyl alcohol / 1 h / 20 °C

With Benzophenone imine; sodium tetrahydroborate; sodium azide; oxalyl dichloride; water; sodium t-butanolate; phosphorus(V) oxybromide; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N,N-dimethyl-formamide; In 1,4-dioxane; diphenyl ether-biphenyl eutectic; dichloromethane; water; isopropyl alcohol; acetone; toluene; acetonitrile;

Reference yield:

: 1365991-85-0
(E)-3-(2-(2,6-dichlorophenyl)thiazol-4-yl)acryloyl chloride

: 1365990-88-0
(1R,2S)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-(hydroxymethyl)cyclopropanecarboxamide

: 1365990-89-1
(1S,2R)-N-(2-(2,6-dichlorophenyl)thiazolo[5,4-c]pyridin-4-yl)-2-(hydroxymethyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium azide / 1,4-dioxane; water; acetone / 0 °C

2: 1,4-dioxane; diphenyl ether-biphenyl eutectic / 1.25 h / 230 °C

3: phosphorus(V) oxybromide / acetonitrile / 2 h / 100 °C

4: sodium t-butanolate; Benzophenone imine / tris-(dibenzylideneacetone)dipalladium(0); racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl / toluene / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

5: 1,4-dioxane / 2 h / 90 °C

6: water; sodium tetrahydroborate / isopropyl alcohol / 1 h / 20 °C

With Benzophenone imine; sodium tetrahydroborate; sodium azide; water; sodium t-butanolate; phosphorus(V) oxybromide; racemic-2-(di-tert-butylphosphino)-1,1′-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; diphenyl ether-biphenyl eutectic; water; isopropyl alcohol; acetone; toluene; acetonitrile;