3-{[3-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-methyl-4-(4-morpholinyl)benzenesulfonamide

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Chemical Name:3-{[3-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-methyl-4-(4-morpholinyl)benzenesulfonamide
CAS No.:1351087-43-8
Molecular Formula:C₂₂H₂₂ClN₇O₃S
Molecular Weight:499.981
Hs Code.:

Synonyms:3-{[3-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-methyl-4-(4-morpholinyl)benzenesulfonamide

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Chemical Property of 3-{[3-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-methyl-4-(4-morpholinyl)benzenesulfonamide

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Technology Process of 3-{[3-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-methyl-4-(4-morpholinyl)benzenesulfonamide

There total 3 articles about 3-{[3-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-methyl-4-(4-morpholinyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1351087-36-9
3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(4-morpholinyl)benzenesulfonamide

: 63503-60-6
3-chlorophenylboronic acid

: 1351087-43-8
3-{[3-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-methyl-4-(4-morpholinyl)benzenesulfonamide

Guidance literature:: 3-[(3-bromo-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-methyl-4-(4-morpholinyl)benzenesulfonamide; 3-chlorophenylboronic acid; With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 90 ℃; Inert atmosphere;

In water;

Reference yield:

: 90914-41-3
3-bromo-4-chloropyrazolo<3,4-d>pyrimidine

: 1351087-43-8
3-{[3-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-methyl-4-(4-morpholinyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: silver trifluoromethanesulfonate / 1,4-dioxane / 80 °C / Sealed flask

2: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 90 °C / Inert atmosphere

With silver trifluoromethanesulfonate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water;

Reference yield:

: 1154161-03-1
3-amino-4-(morpholino)-N-methylbenzenesulfonamide

: 1351087-43-8
3-{[3-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}-N-methyl-4-(4-morpholinyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: silver trifluoromethanesulfonate / 1,4-dioxane / 80 °C / Sealed flask

2: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 90 °C / Inert atmosphere

With silver trifluoromethanesulfonate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water;