2-[4-(tert-butyldimethylsilanyloxy)phenyl]-N-(2-iodophenyl)-N-methylacetamide

Base Information

Chemical Name:2-[4-(tert-butyldimethylsilanyloxy)phenyl]-N-(2-iodophenyl)-N-methylacetamide
CAS No.:835873-18-2
Molecular Formula:C₂₁H₂₈INO₂Si
Molecular Weight:481.449
Hs Code.:

Synonyms:2-[4-(tert-butyldimethylsilanyloxy)phenyl]-N-(2-iodophenyl)-N-methylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[4-(tert-butyldimethylsilanyloxy)phenyl]-N-(2-iodophenyl)-N-methylacetamide

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Technology Process of 2-[4-(tert-butyldimethylsilanyloxy)phenyl]-N-(2-iodophenyl)-N-methylacetamide

There total 1 articles about 2-[4-(tert-butyldimethylsilanyloxy)phenyl]-N-(2-iodophenyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 2-[4-(tert-butyldimethylsilyloxy)phenyl]acetyl chloride

: 57056-93-6
N-methyl-2-iodoaniline

: 835873-18-2
2-[4-(tert-butyldimethylsilanyloxy)phenyl]-N-(2-iodophenyl)-N-methylacetamide

Guidance literature:: With pyridine; dmap; In dichloromethane; at 20 ℃; for 10h;
DOI:10.1021/ol0477226

Reference yield: 88.0%

: 835873-18-2
2-[4-(tert-butyldimethylsilanyloxy)phenyl]-N-(2-iodophenyl)-N-methylacetamide

: 835873-21-7
2-(4-hydroxyphenyl)-N-(2-iodophenyl)-N-methylacetamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.166667h;
DOI:10.1021/ol0477226

Reference yield:

: 835873-18-2
2-[4-(tert-butyldimethylsilanyloxy)phenyl]-N-(2-iodophenyl)-N-methylacetamide

: 835873-22-8
N-(2-iodophenyl)-N-methyl-2-(4-trityloxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / Bu₄NF / tetrahydrofuran / 0.17 h / 20 °C

2: 76 percent / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂ / 3 h

With dmap; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol0477226