5-(3-Benzoyl-thioureido)-1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid amide

Base Information

• Chemical Name: 5-(3-Benzoyl-thioureido)-1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid amide
• CAS No.: 186416-94-4
• Molecular Formula: C₁₈H₁₆N₆O₂S
• Molecular Weight: 380.43
• Mol file: 186416-94-4.mol

Synonyms:5-(3-Benzoyl-thioureido)-1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid amide

Chemical Property of 5-(3-Benzoyl-thioureido)-1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-Benzoyl-thioureido)-1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid amide

There total 2 articles about 5-(3-Benzoyl-thioureido)-1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-amino-3-benzyl-1,2,3-triazole-5-carboxamide (4342-08-9) + Benzoyl isothiocyanate (532-55-8) → 5-(3-Benzoyl-thioureido)-1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid amide (186416-94-4)

Guidance literature:

In acetone; for 48h; Heating;

DOI:10.1002/jhet.5570330609

Reference yield:

benzyl azide (622-79-7) → 5-(3-Benzoyl-thioureido)-1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid amide (186416-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NaOEt / ethanol / 4 h / Heating

2: 80 percent / acetone / 48 h / Heating

With sodium ethanolate; In ethanol; acetone;

DOI:10.1002/jhet.5570330609

Reference yield: 90.0%

5-(3-Benzoyl-thioureido)-1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid amide (186416-94-4) → 1-Benzyl-5-thioureido-1H-[1,2,3]triazole-4-carboxylic acid amide (186416-96-6)

Guidance literature:

With potassium carbonate; In methanol; acetone; for 6h; Heating;

DOI:10.1002/jhet.5570330609

upstream raw materials:

4-amino-3-benzyl-1,2,3-triazole-5-carboxamide

Benzoyl isothiocyanate

benzyl azide

Downstream raw materials:

1-Benzyl-5-thioureido-1H-[1,2,3]triazole-4-carboxylic acid amide

5-(3-Benzoyl-2-methyl-isothioureido)-1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid amide

9-benzyl-8-azaguanine